Population-based study of the effectiveness of bone-specific drugs in reducing the risk of osteoporotic fracture

Pharmacoepidemiology and Drug Safety
Sylvie PerreaultJulio Cesar Fernandes

Abstract

Evidence supports bone-specific drugs (BSDs) efficacy in the fracture risk reduction. But treatment rates for osteoporosis among high-risk patients are far below the recommended guidelines. A major concern about BSDs is the lack of adherence with treatment. To determine if BSDs decrease fracture risk in high-risk elderly women in real clinical setting. A nested case-control design was used in a cohort of elderly women from the Quebec health databases. Women enter into the cohort if they are 70 years or older between 1995 and 2003. Nested case-controls were designed for women with a diagnosis of osteoporosis (OP) and for those with a prior fracture. All cases of fractures occurring during follow-up were matched with 10 randomly selected controls based on age, time period, bone mass density testing, and having a diagnosis of OP or a prior fracture. Use of BSDs before the index date was categorized as follows: short-term (< or =1 year), intermediate-term (>1 and < or = 3 years), and long-term (>3 years). We used an adjusted conditional logistic regression model to assess BSD effect on fracture. Among 3170 women who had a fracture, of these women, 1824 had OP and 1346 had a prior fracture. Only long-term exposure to BSDs among wome...Continue Reading

References

Apr 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B EttingerH K Genant
Mar 23, 1995·The New England Journal of Medicine·S R CummingsT M Vogt
Jun 1, 1993·The American Journal of Medicine·K W LylesP L Mulhausen
Jun 1, 1993·Arthritis and Rheumatism·D J CookE F Juniper
Mar 12, 1998·The New England Journal of Medicine·R Eastell
Oct 20, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Allolio
Feb 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ReginsterR Eastell
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Feb 24, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A TenenhouseUNKNOWN CaMos Research Group.Canadian Multicentre Osteoporosis Study
Jun 26, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M E WiktorowiczE Papadimitropoulos
Feb 28, 2002·Archives of Internal Medicine·Teresa C GallagherFlorence Comite
May 7, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A G Juby, C M De Geus-Wenceslau
May 22, 2002·Archives of Internal Medicine·Michael MaricicKristine D Harper
May 31, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S E GabrielL J Melton
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Jun 22, 2002·Lancet·Pierre D Delmas
Apr 30, 2003·Archives of Internal Medicine·Kristine E EnsrudUNKNOWN Study of Osteoporotic Fractures Research Group
Sep 2, 2003·The American Journal of Medicine·Anna N A TostesonBruce Ettinger
Sep 25, 2003·Archives of Internal Medicine·Susan E AndradeJerry H Gurwitz
Nov 18, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Martien J M PannemanRon M C Herings
May 29, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Jaime CaroChristel Naujoks
Jul 20, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V Elliot-GibsonD E Beaton
Jan 13, 2005·Pharmacoepidemiology and Drug Safety·Sylvie PerreaultJulio Cesar Fernandès
Dec 28, 2005·The American Journal of Medicine·Mitsuyo KinjoDaniel H Solomon
Sep 14, 2006·Current Medical Research and Opinion·C H A van den BoogaardR M C Herings
Oct 6, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D WeyckerG Oster
Jan 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Julie BlouinSylvie Perreault

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Citations

Nov 21, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O SheehyJ LeLorier
Sep 2, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A AbelsonT Thomas
Nov 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M-C LalibertéL Lalonde
May 29, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V RabendaJ-Y Reginster
Jan 13, 2011·Journal of Bone and Mineral Metabolism·Serge FerrariNelson B Watts
Mar 18, 2010·Archives of Osteoporosis·Kristina Johnell, Johan Fastbom
May 12, 2009·The Journal of Trauma·Marie-Josée SiroisStéphane Pelet
Sep 10, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D XingY Chen
Dec 31, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·José Antonio Martínez PérezMaite Pérez
Dec 20, 2011·Expert Opinion on Drug Metabolism & Toxicology·Slobodan M Jankovic, Milivoje Dostic
Mar 17, 2010·The American Journal of Geriatric Pharmacotherapy·Richard H LeeCathleen Colón-Emeric
Jan 9, 2013·Pharmacoepidemiology and Drug Safety·Lisa GoltzChristoph Schindler
Jun 10, 2014·Pharmacoepidemiology and Drug Safety·Giovanni CorraoUNKNOWN BEST investigators
Jun 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Susan RossEthel Siris

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