Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis

Journal of Gastroenterology and Hepatology
Colin A SherringtonJohn K Olynyk

Abstract

Mutations in the hemochromatosis (HFE) gene are carried by one in three individuals of British Isles descent and may result in increased iron stores. These increased iron stores could potentially induce or exacerbate diseases, such as arthritis, in which iron has a role in pathogenesis. Although arthritis is a well-known association of clinically overt hereditary hemochromatosis, controversy surrounds the role of mutations in the HFE gene as risk factors for arthritis. The aim of the present study was to determine whether mutations in the HFE gene are associated with an increased prevalence of arthritis. A population-based study was conducted in Busselton, Western Australia, of the prevalence of arthritis in 1372 individuals of British Isles descent. Participants completed a questionnaire and general physical examination. Analysis for C282Y and H63D HFE mutations was undertaken. Unadjusted and adjusted odds ratios (OR) were calculated for the relationship between HFE mutations and the prevalence of self-reported, doctor-diagnosed arthritis. There was no association between the presence of HFE mutations and the prevalence of self-reported, doctor-diagnosed arthritis (C282Y/wild type (WT) adjusted OR = 1.041 (95% confidence inter...Continue Reading

References

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Citations

Jan 3, 2012·Seminars in Arthritis and Rheumatism·Yuanyuan WangFlavia M Cicuttini
Oct 24, 2008·Alimentary Pharmacology & Therapeutics·C J CrooksT R Card
Aug 5, 2010·The Journal of Rheumatology·Pascal RichetteThomas Bardin
Sep 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oyekoya T Ayonrinde, John K Olynyk
May 8, 2007·International Journal of Hematology·Barbara Kaczorowska-HacAnna Balcerska
Aug 21, 2008·Critical Reviews in Clinical Laboratory Sciences·Oyekoya T AyonrindeJohn K Olynyk
Jan 19, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jone TamosauskaiteDavid Melzer

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