Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan

Vaccine
Romena QaziAnita K M Zaidi

Abstract

The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and stools were obtained from 575 (80%) with 97 (17%) being rotavirus positive. Adjusted annual rates of severe rotavirus diarrhoea in children less than five years and less than one year were respectively 5.7 and 16.9 per 1000 in community A, and 8.1 and 25.4 per 1000 child years of observation in community B. An estimated 1 in 40 infants experience a severe episode of rotavirus gastroenteritis annually in Pakistan. The most common rotavirus strains were G9P[8] (15%), G1P[8] (13%) and G1[P4] (8.4%). This information will inform policy decisions about the introduction of rotavirus vaccines.

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Citations

Nov 30, 2012·The Pediatric Infectious Disease Journal·Manish M PatelUmesh D Parashar
Dec 18, 2013·The Pediatric Infectious Disease Journal·Sammy KhagayiKayla F Laserson
Jan 10, 2013·Epidemiology and Infection·T R ChandolaN Bhandari
Oct 20, 2012·Journal of Medical Virology·Tayyba IftikharAbdul Haque
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Oct 9, 2014·PloS One·Abdul Momin KaziUNKNOWN members of the Pakistan Rotavirus Study Group
Apr 10, 2019·Human Vaccines & Immunotherapeutics·Selim BadurDebasish Saha
Dec 19, 2019·Journal of Global Infectious Diseases·Arpit Kumar ShrivastavaRashmi Ranjan Das
Jan 7, 2021·Indian Journal of Pediatrics·Subal Kumar PradhanSaroj Kumar Satpathy
May 27, 2021·Zeitschrift für Gesundheitswissenschaften = Journal of public health·Muhammad Ashraf Khan
Jun 1, 2010·Medicine·M Sánchez Conde

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