Population-based validation of the National Cancer Comprehensive Network recommendations for breast cancer staging

Breast Cancer Research and Treatment
Omar Abdel-Rahman

Abstract

The aim of the current study is to evaluate the performance characteristics of the National Comprehensive Cancer Network (NCCN) staging recommendations for breast cancer with regard to the detection of lung, bone, and liver metastases. Surveillance, epidemiology, and end points (SEER) database (2010-2015) was accessed, and patients with breast cancer and complete information about T stage and clinical N stage, ER status, Her2 status, and metastatic sites were extracted. Performance characteristics evaluated for the current study included sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), number needed to investigate (NNI), and accuracy. A total of 239,196 patients were included in the analysis. For the overall cohort, the required PPV (for the recognition of lung metastases) is 10.6% and NNI to detect one case of lung metastasis is 9.4. Likewise, PPV (for the recognition of bone metastases) is 18.6% and NNI to detect one case of bone metastasis is 5.3. Moreover, PPV (for the recognition of liver metastases) is 7.6% and NNI to detect one case of liver metastasis is 13.1. When changing the threshold for baseline imaging to includeT2N1 patients, a better balance between sensitivity and spec...Continue Reading

References

Jan 10, 2012·World Journal of Surgical Oncology·Hyung Seok ParkSang Seol Jung
Dec 7, 2013·JAMA Surgery·Sanjay P BagariaArmando E Giuliano
Jan 20, 2017·Virchows Archiv : an International Journal of Pathology·István Artúr MolnárAnna-Mária Tőkés
Nov 17, 2017·Breast Cancer Research and Treatment·Omar Abdel-Rahman
May 23, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Sharon H GiordanoWilliam J Gradishar

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Citations

Oct 23, 2019·Journal of Comparative Effectiveness Research·Omar Abdel-Rahman, Winson Y Cheung
Mar 12, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O Abdel-RahmanW Y Cheung

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