Population distribution of the methionine allele at the PRNP codon 129 polymorphism in Europe and the Middle East

Human Biology
Géraldine MercierGérard Lucotte

Abstract

Methionine homozygosity at codon 129 of the prion protein gene is a risk factor for Creutzfeldt-Jakob disease. Knowledge of M129V polymorphism in normal populations may contribute to a better understanding of prion diseases. M129V polymorphism was studied in 2201 normal subjects, originating from 15 populations from Europe and the Middle East. Mean heterozygosity in these populations is 38.9%, and there is some significant geographic heterogeneity between them. A comparison of M129 allele frequencies in these 15 populations to those already published for 8 European countries plus Turkey shows significant correlations with both latitude (r = -0.77) and longitude (r = 0.69). The geographic map of methionine allele frequencies indicates an east-west gradient of decreasing methionine allele values from the Middle East to Western Europe.

References

Feb 24, 2001·Revue Scientifique Et Technique·M Zeidler, J W Ironside
Jan 11, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gérard Lucotte, Géraldine Mercier

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Citations

May 23, 2012·Emerging Infectious Diseases·Paul BrownLawrence B Schonberger
May 8, 2013·Emerging Infectious Diseases·Edgar HolznagelJohannes Loewer

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Arcview
Spatial Analyst

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