Population distributions of minimum inhibitory concentration--increasing accuracy and utility

Journal of Applied Microbiology
R J W Lambert, R Lambert

Abstract

To generate continuous minimum inhibitory concentration (MIC) data that describes the discrete nature of experimentally derived population MIC data. A logistic model was fitted to experimentally derived MIC population cumulative distributions from clinical isolates of Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae and Staphylococcus aureus (European Committee on Antimicrobial Susceptibility Testing, BSAC and MYSTIC population susceptibility databases). From the model continuous distributions of population susceptibility were generated. The experimentally observed population distributions based on discrete MIC could be reproduced from this underlying continuous distribution. Monte Carlo (MC) simulation was used to confirm findings. Where the discrete experimental data contained few or no isolates with MIC greater or less than the antimicrobial concentration range tested, the true mean MIC was a factor of 0.707 times that normally reported and may be of little clinical significance. Where data contained isolates beyond the range of concentration used, the true MIC was dependent on the SD and the number of isolates and could be clinically significant. Subpopulations of differing susceptibilities could be m...Continue Reading

References

Jun 23, 2001·The Journal of Antimicrobial Chemotherapy·J M Andrews
Jun 23, 2001·The Journal of Antimicrobial Chemotherapy·A P MacGowan, R Wise
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·Deirdre Lewis
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·A K Morris, R G Masterton
Apr 30, 2002·International Journal of Antimicrobial Agents·Johan W Mouton
Sep 20, 2002·The Journal of Antimicrobial Chemotherapy·David Felmingham

❮ Previous
Next ❯

Citations

Feb 18, 2015·The Science of the Total Environment·Girija Page, Bill Bellotti
Mar 13, 2014·Antimicrobial Agents and Chemotherapy·Julianne KimAndrew Simor
Oct 25, 2008·Annals of Surgery·Jonathan R TreadwellKaren Schoelles
Jun 15, 2013·Blood·UNKNOWN Sylvie Castaigne
Apr 10, 2013·Blood·Guanfang ShiCraig N Morrell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.