Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle

Scientific Reports
Naomi OhtaH Morgan Scott

Abstract

A randomized controlled longitudinal field trial was undertaken to assess the effects of injectable ceftiofur crystalline-free acid (CCFA) versus in-feed chlortetracycline on the temporal dynamics of Salmonella enterica spp. enterica in feedlot cattle. Two replicates of 8 pens (total 176 steers) received one of 4 different regimens. All, or one, out of 11 steers were treated with CCFA on day 0 in 8 pens, with half of the pens later receiving three 5-day regimens of chlortetracycline from day 4 to day 20. Salmonella was isolated from faecal samples and antimicrobial susceptibility was analysed via microbroth dilution. Serotype was determined by whole-genome sequencing. On day 0, mean Salmonella prevalence was 75.0% and the vast majority of isolates were pansusceptible. Both antimicrobials reduced overall prevalence of Salmonella; however, these treatments increased the proportion of multi-drug resistant (MDR) Salmonella from day 4 through day 26, which was the last day of faecal collection. Only six Salmonella serotypes were detected. Salmonella serotype Reading isolates were extensively MDR, suggesting a strong association between serotype and resistance. Our study demonstrates that the selection pressures of a 3rd generation c...Continue Reading

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Citations

May 8, 2018·Applied and Environmental Microbiology·Margaret D WeinrothKeith E Belk
May 28, 2019·Microbiology Resource Announcements·Selma GonzalezKeri N Norman
Mar 31, 2021·Antimicrobial Agents and Chemotherapy·Amy T SiceloffNikki W Shariat

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Methods Mentioned

BETA
DNA Assay

Software Mentioned

- TET
SeqSero pipeline
Stata
- SUL
Tableau Desktop
SWIN
STR

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