Population Dynamics of Underdominance Gene Drive Systems in Continuous Space.

ACS Synthetic Biology
Jackson ChamperPhilipp W Messer

Abstract

Underdominance systems can quickly spread through a population, but only when introduced in considerable numbers. This promises a gene drive mechanism that is less invasive than homing drives, potentially enabling new approaches in the fight against vector-borne diseases. If regional confinement can indeed be achieved, the decision-making process for a release would likely be much simpler compared to other, more invasive types of drives. The capacity of underdominance gene drive systems to spread in a target population without invading other populations is typically assessed via network models of panmictic demes linked by migration. However, it remains less clear how such systems would behave in more realistic population models where organisms move over a continuous landscape. Here, we use individual-based simulations to study the dynamics of several proposed underdominance systems in continuous-space. We find that all these systems can fail to persist in such environments, even after an initially successful establishment in the release area, confirming previous theoretical results from diffusion theory. At the same time, we find that a two-locus two-toxin-antidote system can invade connected demes through a narrow migration co...Continue Reading

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Citations

Feb 29, 2020·Nature Communications·Jackson ChamperPhilipp W Messer
Mar 14, 2020·BMC Biology·Jackson ChamperPhilipp W Messer
Oct 10, 2020·Annual Review of Entomology·Bruce A HayMing Guo
Mar 6, 2021·Evolutionary Applications·Nathan C LaymanScott L Nuismer
Mar 17, 2021·Genetics·Richard GomulkiewiczJames J Bull
Apr 27, 2021·Evolutionary Applications·Jackson ChamperPhilipp W Messer
Aug 8, 2021·Nature Reviews. Genetics·Ethan Bier
Aug 11, 2021·BMC Ecology and Evolution·Prateek VermaChaitanya S Gokhale
Aug 10, 2021·Annual Review of Ecology, Evolution, and Systematics·Sumit DholeFred Gould

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