PMID: 11922427Apr 2, 2002Paper

Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection

Parasitology
J A SimpsonN J White

Abstract

A retrospective analysis was performed of parasite count data recorded from the first 7 days of blood or mosquito transmitted Plasmodium falciparum infections given for the treatment of neurosyphilis in the USA before 1963. The objective of this study was to characterize initial growth dynamics before host defences have significant effects on the infecting parasite population. Of the 328 patients' data available for analysis, 83 were excluded because they had received anti-malarial treatment during the first 7 days of the patent infection. Nonlinear mixed effects modelling was performed to estimate the parameters of interest; 'parasite multiplication rate per 48 h' (PMR), and length of the parasite life-cycle (periodicity). The parasitaemia versus time profiles showed great variability between patients. The mean population estimate of 'PMR' was approximately 8, and was highly dependent on the P. falciparum 'strain'. PMR also varied significantly between patients with a 90% prediction interval varying from 5.5 to 12.3-fold. Both intrinsic parasite multiplication rate (an intrinsic virulence determinant), and host susceptibility and defence contribute to expansion of the parasite biomass and thus disease severity in falciparum ma...Continue Reading

Citations

Oct 16, 2002·Trends in Parasitology·Nicholas J White
Mar 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel P WebsterAdrian V S Hill
Apr 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jacob E LemieuxChris I Newbold
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter D CromptonSusan K Pierce
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sompob SaralambaLisa J White
Mar 19, 2003·Proceedings. Biological Sciences·N J White, W Pongtavornpinyo
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Margaret J Mackinnon, Andrew F Read
Feb 27, 2008·Antimicrobial Agents and Chemotherapy·K Stepniewska, N J White
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·S PukrittayakameeN J White
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·M Le JouanG Pons
Jan 16, 2007·Clinical Microbiology Reviews·David J Conway
Oct 27, 2004·Infection and Immunity·Michelle L Gatton, Qin Cheng
Jan 12, 2008·Malaria Journal·Nicholas J White
Nov 13, 2009·Malaria Journal·Nicholas J WhiteNicholas P J Day
Oct 25, 2012·PLoS Computational Biology·Mykola PinkevychMiles P Davenport
Aug 18, 2005·PLoS Medicine·Arjen M DondorpNicholas P J Day
May 14, 2010·PloS One·Beth F KochinRustom Antia
Dec 3, 2010·The Journal of Clinical Investigation·Peter D CromptonLouis H Miller
Jan 28, 2014·The American Naturalist·Megan A GreischarOttar N Bjørnstad
Dec 29, 2015·Trends in Parasitology·Beatriz GalatasAlfredo Mayor
Jul 12, 2008·Trends in Parasitology·Anna Färnert
Jul 6, 2004·Immunological Reviews·Anne C Moore, Adrian V S Hill
Apr 16, 2004·The Journal of Clinical Investigation·Nicholas J White
Aug 21, 2013·Lancet·Nicholas J WhiteArjen M Dondorp
Oct 3, 2012·PloS One·Ingrid FelgerThomas A Smith
Jun 19, 2015·PLoS Pathogens·Sandra K NilssonMatthias Marti
Nov 23, 2013·The Journal of Infectious Diseases·Mykola PinkevychMiles P Davenport
Sep 11, 2013·The American Journal of Tropical Medicine and Hygiene·Mykola PinkevychMiles P Davenport

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