PMID: 9662203Jul 14, 1998Paper

Population effects of preventive and therapeutic HIV vaccines in early- and late-stage epidemics

AIDS
Douglas K OwensR D Shachter

Abstract

To evaluate the population effects of potential preventive and therapeutic vaccines in early- and late-stage epidemics in a population of homosexual men. An epidemic model was used that simulated the course of the epidemic for a population of homosexual men in San Francisco, California. Vaccine programs were evaluated by the number of cases of HIV averted, the effect on the prevalence of HIV, and by the gain in quality-adjusted life years (QALY) for the total population. In the model, a preventive vaccine prevented 3877 cases of HIV infection during a 20-year period, reduced the projected prevalence of HIV infection from 12 to 7% in a late-stage epidemic, and gained 15,908 QALY. A therapeutic vaccine that did not affect the infectivity of vaccine recipients increased the number of cases of HIV infection by 210, resulted in a slight increase in the prevalence of HIV infection from 12 to 15% in a late-stage epidemic, and gained 8854 QALY. If therapeutic vaccines reduced infectivity, their use could produce net gains of QALY in the population that were similar to gains from the use of preventive vaccines. In an early-stage epidemic, the advantage of a preventive vaccine program relative to a therapeutic vaccine program was markedl...Continue Reading

References

Nov 22, 1991·Proceedings. Biological Sciences·M A Nowak, A R McLean
Feb 1, 1991·The Journal of Infectious Diseases·J WintschJ M Dayer
Aug 1, 1990·American Journal of Public Health·M L Ekstrand, T J Coates
Nov 16, 1995·The New England Journal of Medicine·B S Graham, P F Wright
Jun 22, 1995·Proceedings. Biological Sciences·S k Service, S M Blower
May 1, 1995·Annals of Internal Medicine·D K OwensR F Nease
Jul 22, 1993·Proceedings. Biological Sciences·A R McLean, S M Blower

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Citations

Mar 18, 2004·Bio Systems·Henry C Tuckwell, Frederic Y M Wan
May 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mina HosseinipourAngela D M Kashuba
Nov 17, 2009·AIDS Patient Care and STDs·Christopher D NettlesKristina A Uban
Sep 29, 2004·Journal of Virology·Miles P DavenportAlan S Perelson
Sep 21, 2011·European Journal of Epidemiology·Narat PunyacharoensinRichard Guy White
Apr 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Susan P BuchbinderEric Vittinghoff
Jun 28, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Grant ColfaxBrad Bartholow
Sep 5, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sam AmirfarSalim S Abdool Karim
Feb 23, 2008·The Lancet Infectious Diseases·Marie-Claude BoilyRoy Anderson
Feb 8, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elizabeth Bogard, Karen M Kuntz
Sep 11, 2014·PloS One·Andrew N PhillipsThierry Van Effelterre
May 7, 1999·Medical Decision Making : an International Journal of the Society for Medical Decision Making·A RichterD K Owens
Aug 2, 2003·Current Opinion in Pediatrics·Elyse Olshen, Cathryn L Samples
Apr 20, 2002·Current Opinion in Infectious Diseases·David A. Hawkins
Mar 15, 2000·AIDS·S D PinkertonJ G Kahn

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