Population genetics of benzimidazole-resistant Haemonchus contortus and Haemonchus placei from buffalo and cattle: implications for the emergence and spread of resistance mutations

Parasitology Research
Qasim AliUmer Chaudhry

Abstract

The population genetics of nematode parasites are poorly understood with practical reference to the selection and spread of anthelmintic resistance mutations. Haemonchus species are important to study the nematode population genetics due to their clinical importance in ruminant livestock, and the availability of genomic resources. In the present study, it has been examined that Haemonchus contortus and Haemonchus placei populations from three buffalo and nine cattle hosts. Seventy-three individual adult worms of H. contortus and 148 of H. placei were analysed using a panel of seven microsatellite markers. The number of alleles per locus in H. contortus and H. placei indicated that all populations were polymorphic for the microsatellites used in the present study. Genetic diversity parameters included high levels of allelic richness and heterozygosity, indicating effective population sizes, high mutation rates and high transmission frequencies in the area. Genetic structure parameters revealed low genetic differentiation between and high levels of genetic variation within H. contortus and H. placei populations. Population dynamic analyses showed an absence of heterozygosity excess in both species, suggesting that there was no de...Continue Reading

References

Jun 20, 2003·International Journal for Parasitology·Karin TroellJohan Höglund
Oct 3, 2006·Veterinary Parasitology·Lauren J O'ConnorLewis P Kahn
Jul 5, 2007·Parasitology·J S Gilleard, R N Beech
Dec 11, 2007·International Journal for Parasitology·P W HuntL J Anderson
Sep 11, 2010·International Journal for Parasitology·Elizabeth A Archie, Vanessa O Ezenwa
Dec 14, 2011·Veterinary Parasitology·Ray M Kaplan, Anand N Vidyashankar
Jul 13, 2012·International Journal for Parasitology·Bruno S A F BrasilDenise A A Oliveira
May 31, 2016·Advances in Parasitology·J S Gilleard, E Redman
Jan 1, 1989·Evolution; International Journal of Organic Evolution·William R Rice

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Citations

Sep 27, 2020·Acta Parasitologica·Shawky M AboelhadidSahar M Gadelhaq
Feb 10, 2021·Parasites & Vectors·Khalid M MohammedsalihGeorg von Samson-Himmelstjerna
Aug 8, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Opal PitaksakulratPaiboon Sithithaworn
Oct 26, 2020·Preventive Veterinary Medicine·Flávia C FáveroFernando de A Borges

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

AMOVA
PSQ
GenALEx
Gene Mapper
Arlequin

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Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.