Population genetics of non-genetic traits: evolutionary roles of stochasticity in gene expression

Gene
Katsuhiko MinetaHitoshi Araki

Abstract

The role of stochasticity in evolutionary genetics has long been debated. To date, however, the potential roles of non-genetic traits in evolutionary processes have been largely neglected. In molecular biology, growing evidence suggests that stochasticity in gene expression (SGE) is common and that SGE has major impacts on phenotypes and fitness. Here, we provide a general overview of the potential effects of SGE on population genetic parameters, arguing that SGE can indeed have a profound effect on evolutionary processes. Our analyses suggest that SGE potentially alters the fate of mutations by influencing effective population size and fixation probability. In addition, a genetic control of SGE magnitude could evolve under certain conditions, if the fitness of the less-fit individual increases due to SGE and environmental fluctuation. Although empirical evidence for our arguments is yet to come, methodological developments for precisely measuring SGE in living organisms will further advance our understanding of SGE-driven evolution.

References

Oct 1, 1987·Heredity·T A Mousseau, D A Roff
Dec 29, 1972·Journal of Molecular Evolution·M Kimura, T Ota
Sep 1, 1966·Journal of Theoretical Biology·D Cohen
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·D L CookS J Tapscott
Jun 1, 2000·Molecular Biology and Evolution·T PupkoD Graur
Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ralf KemkemerDieter Kaufmann
May 29, 2004·Genetics·Mukund Thattai, Alexander van Oudenaarden
Jun 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hunter B FraserMichael B Eisen
Mar 26, 2005·Science·Juan M Pedraza, Alexander van Oudenaarden
May 11, 2005·Nature Reviews. Genetics·Mads KaernJames J Collins
Sep 20, 2005·Nature·Alejandro Colman-LernerRoger Brent
Sep 24, 2005·Science·Jonathan M Raser, Erin K O'Shea
May 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jerome T MettetalAlexander van Oudenaarden
May 23, 2006·Current Biology : CB·Jonathan R ChubbRobert H Singer
Jun 30, 2006·Trends in Genetics : TIG·Yoav GiladScott A Rifkin
Jul 31, 2007·Nature Genetics·Nizar N Batada, Laurence D Hurst
Mar 26, 2008·Nature Genetics·Murat AcarAlexander van Oudenaarden
Apr 5, 2008·Science·Richard Losick, Claude Desplan
May 2, 2008·Genome Research·Itay Tirosh, Naama Barkai
Jul 30, 2008·Current Opinion in Biotechnology·Vahid Shahrezaei, Peter S Swain
Oct 30, 2008·Cell·Arjun Raj, Alexander van Oudenaarden
Jan 31, 2009·Trends in Ecology & Evolution·Thomas LenormandFrançois Rousset
Mar 3, 2009·Nature Genetics·Jung Kyoon Choi, Young-Joon Kim
Aug 20, 2009·Molecular Systems Biology·Zhihua ZhangJianzhi Zhang
Jun 23, 2010·Annual Review of Genomics and Human Genetics·Masatoshi NeiMasafumi Nozawa
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zhi Wang, Jianzhi Zhang
Oct 8, 2011·Genome Biology and Evolution·Tomoko Ohta
Apr 14, 2012·Science·Brian MunskyAlexander van Oudenaarden
Sep 12, 2012·Genetics·Hiroshi AkashiTomoko Ohta
Dec 1, 1972·Journal of Molecular Evolution·T Ohta
Dec 7, 2013·Science·Alvaro Sanchez, Ido Golding
Sep 5, 2014·Nature·Daniel J KivietSander J Tans

❮ Previous
Next ❯

Citations

Dec 3, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hannah DueckJunhyong Kim
Nov 8, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Markus M M BisschopsPascale Daran-Lapujade
May 20, 2017·Nature Communications·Sinisa BratulicAndreas Wagner
Feb 9, 2019·Evolution; International Journal of Organic Evolution·Salomé BourgEtienne Rajon
Aug 21, 2020·Evolution; International Journal of Organic Evolution·Charles RocabertSamuel Bernard
Oct 27, 2020·PLoS Computational Biology·Michael Schmutzer, Andreas Wagner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Autonomic Neuroscience : Basic & Clinical
Karl Martin Klein, Samuel F Berkovic
Evolution; International Journal of Organic Evolution
David L Stern, Virginie Orgogozo
© 2022 Meta ULC. All rights reserved