Population Genetics of Plasmodium vivax in the Peruvian Amazon

PLoS Neglected Tropical Diseases
Christopher Delgado-RattoUmberto D'Alessandro

Abstract

Characterizing the parasite dynamics and population structure provides useful information to understand the dynamic of transmission and to better target control interventions. Despite considerable efforts for its control, vivax malaria remains a major health problem in Peru. In this study, we have explored the population genetics of Plasmodium vivax isolates from Iquitos, the main city in the Peruvian Amazon, and 25 neighbouring peri-urban as well as rural villages along the Iquitos-Nauta Road. From April to December 2008, 292 P. vivax isolates were collected and successfully genotyped using 14 neutral microsatellites. Analysis of the molecular data revealed a similar proportion of monoclonal and polyclonal infections in urban areas, while in rural areas monoclonal infections were predominant (p = 0.002). Multiplicity of infection was higher in urban (MOI = 1.5-2) compared to rural areas (MOI = 1) (p = 0.003). The level of genetic diversity was similar in all areas (He = 0.66-0.76, p = 0.32) though genetic differentiation between areas was substantial (PHIPT = 0.17, p<0.0001). Principal coordinate analysis showed a marked differentiation between parasites from urban and rural areas. Linkage disequilibrium was detected in all th...Continue Reading

References

May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J M SmithB G Spratt
Apr 30, 1999·Emerging Infectious Diseases·J Aramburú GuardaR Witzig
Jun 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·J M RubioM Hommel
Mar 16, 2007·The Journal of Infectious Diseases·Marcelo U FerreiraDaniel L Hartl
Apr 20, 2007·International Journal for Parasitology·Mallika ImwongTim J C Anderson
Dec 10, 2009·The American Journal of Tropical Medicine and Hygiene·Pamela Orjuela-SánchezMarcelo Urbano Ferreira
Feb 6, 2010·The American Journal of Tropical Medicine and Hygiene·Peter Van den EedeUmberto D'Alessandro
Apr 12, 2012·The American Journal of Tropical Medicine and Hygiene·Margaret KosekJoseph M Vinetz
Apr 13, 2012·Nature Reviews. Genetics·Sarah K VolkmanDyann F Wirth
May 10, 2012·BMC Bioinformatics·Alexandre P FranciscoJoäo A Carriço
Aug 17, 2012·The Journal of Heredity·Patrick G Meirmans
Sep 13, 2012·PLoS Neglected Tropical Diseases·Peter W GethingSimon I Hay
Dec 13, 2012·Malaria Journal·Stella M ChenetAnanias A Escalante
Feb 7, 2013·Advances in Parasitology·Jane M CarltonAnanias A Escalante
Sep 5, 2013·Malaria Journal·Sean M GriffingVenkatachalam Udhayakumar
Feb 1, 2014·Advances in Parasitology·Michel Tibayrenc, Francisco J Ayala
Feb 27, 2014·Malaria Journal·Andrea M McCollumDavid J Bacon
Aug 8, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Michela MenegonCarlo Severini
Apr 22, 2015·Pathogens and Global Health·Alyssa E BarryIvo Mueller
Jul 1, 2015·PLoS Neglected Tropical Diseases·Cristian KoepfliIngrid Felger

❮ Previous
Next ❯

Citations

Jul 4, 2017·PLoS Neglected Tropical Diseases·Eduard Rovira-VallbonaAnna Rosanas-Urgell
Sep 5, 2019·Molecular Ecology·Lindsay S MilesBrian C Verrelli
Nov 4, 2017·Science·Marc T J Johnson, Jason Munshi-South
Jul 9, 2016·Expert Review of Proteomics·Apoorva VenkateshSanjeeva Srivastava
Apr 25, 2018·Malaria Journal·Daibin ZhongGuiyun Yan
May 16, 2018·The American Journal of Tropical Medicine and Hygiene·Julio A VentocillaPaul C F Graf
May 12, 2017·Cold Spring Harbor Perspectives in Medicine·John H Adams, Ivo Mueller
Sep 23, 2020·Malaria Journal·Rajika L DewasurendraNadira D Karunaweera
Feb 18, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Carlos Fernandez-MiñopeJean-Pierre Van Geertruyden
Apr 30, 2021·Science Advances·Josquin DaronVirginie Rougeron

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
genotyping

Software Mentioned

DISTRUCT
PHYLOViZ
GENODIVE
MIGRATE
SPSS
eBURST
GenAlEx
AMOVA
FSTAT
BOTTLENECK

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.