Population Histories of the United States Revealed through Fine-Scale Migration and Haplotype Analysis

American Journal of Human Genetics
Chengzhen L. DaiAlicia R. Martin

Abstract

The population of the United States is shaped by centuries of migration, isolation, growth, and admixture between ancestors of global origins. Here, we assemble a comprehensive view of recent population history by studying the ancestry and population structure of more than 32,000 individuals in the US using genetic, ancestral birth origin, and geographic data from the National Geographic Genographic Project. We identify migration routes and barriers that reflect historical demographic events. We also uncover the spatial patterns of relatedness in subpopulations through the combination of haplotype clustering, ancestral birth origin analysis, and local ancestry inference. Examples of these patterns include substantial substructure and heterogeneity in Hispanics/Latinos, isolation-by-distance in African Americans, elevated levels of relatedness and homozygosity in Asian immigrants, and fine-scale structure in European descents. Taken together, our results provide detailed insights into the genetic structure and demographic history of the diverse US population.

Citations

Sep 17, 2020·American Journal of Physical Anthropology·Ken BataiRick A Kittles
Oct 16, 2020·Journal of Human Genetics·Alex Diaz-PapkovichSimon Gravel
Mar 16, 2021·Cancer·Otis W Brawley
Dec 18, 2020·Human Molecular Genetics·Cesar Fortes-Lima, Paul Verdu
May 2, 2021·American Journal of Human Genetics·UNKNOWN Epi25 Collaborative. Electronic address: jm4279@cumc.columbia.edu, UNKNOWN Epi25 Collaborative
May 20, 2021·American Journal of Physical Anthropology·Kip D ZimmermanPaula S Ramos
Sep 10, 2021·Molecular Biology and Evolution·Gautam ShirsekarDetlef Weigel

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