Population kinetic study of guinea pig monocytes and their subsets during acute inflammation

Cellular Immunology
S J Normann, S J Noga

Abstract

Guinea pig peripheral blood monocytes exist in four subsets which differ in cytochemistry, function, rates of production, and circulatory time during steady state. These subsets are designated small, intermediate, large, and very large vacuolated monocytes. To address the question as to whether all subsets participate equally in the acute inflammatory response, population kinetics were performed on monocyte subsets isolated by counterflow centrifugation elutriation following a single intravenous pulse of tritiated thymidine given concurrently with an intraperitoneal injection of phytohemagglutinin as phylogistic agent. Inflammation reduced the cell cycle times of the precursors for all monocyte subsets, increasing their production. However, inflammation increased the number of precursors only for large monocytes. In addition, a reserve of exclusively large monocytes existed which appeared in the circulation within 3 hr of inflammation induction. The subsequent loss of large monocytes from the circulation exceeded their production in contrast to all other monocyte fractions. Over 92% of all monocytes entering the acute inflammatory site were large monocytes despite the fact that they constituted only 58% of monocytes under stead...Continue Reading

References

Feb 1, 1986·The Journal of Experimental Medicine·R van Furth, W Sluiter
Jul 1, 1972·Cell and Tissue Kinetics·D M Whitelaw
Sep 1, 1968·The Journal of Experimental Medicine·R van Furth, Z A Cohn

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