Population-mixing at the place of residence at the time of birth and incidence of childhood leukaemia in France

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
J RudantJ Clavel

Abstract

The association between the risk of childhood leukaemia before age 7 years and population-mixing at the place of residence at birth was investigated by retrospectively considering all the children born in mainland French communes between 1st January 1990 and 31st December 1998. An increased risk of acute lymphoblastic leukaemia was found with higher levels of migration for children residing at birth in isolated communes with a population density > or =50 people per km2 (SIRR = 2.59, 95% CI: 1.48-4.49). No association was observed with lower population densities. For children residing in non-isolated communes at birth, the results were similar but less marked. The risk tended to increase only for population densities > or =5000 people per km2 (SIRR = 1.57, 95% CI: 0.99-2.52). The findings are consistent with epidemic models and support the hypothesis of an infectious aetiology relating to population-mixing. Population density may be seen as an indicator of the opportunity of contacts between inhabitants and should therefore be taken into account when investigating an infectious hypothesis. This is the first systematic study of population-mixing at the place of residence at the time of birth to be conducted on a national scale.

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Citations

Dec 12, 2012·Pathology Oncology Research : POR·T A NyariR J Q McNally
Nov 21, 2007·Médecine sciences : M/S·Daniel SinnettJasmine Healy
Feb 10, 2007·Expert Review of Anticancer Therapy·Sima Jeha, Hagop Kantarjian
May 27, 2015·European Journal of Epidemiology·Judith E LupatschBen D Spycher
Jun 23, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M Tubiana
May 16, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Claire FaureDenis Hémon
Jan 3, 2009·Social Science & Medicine·Laura J MillerRussell S Scott
Mar 17, 2007·Pediatric Blood & Cancer·Brenda R ClarkJohn R Wilkins
Apr 19, 2008·Pediatric Blood & Cancer·Graham R LawPatricia A McKinney
Jun 3, 2016·European Journal of Epidemiology·Judith E LupatschUNKNOWN Swiss National Cohort Study Group
Dec 19, 2007·British Journal of Cancer·S BellecJ Clavel
Oct 24, 2006·FEMS Immunology and Medical Microbiology·Dilys Morgan

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