Population pharmacokinetic analysis to identify the possibility of interaction between anti-cancer agents

Indian Journal of Cancer
J SubramanianS Rohatagi

Abstract

A number of molecularly targeted agents in oncology are tested in clinical studies in combination with conventional chemotherapy and/or radiotherapy. There is the possibility that the pharmacokinetics and dynamics of these targeted agents may be different when administered alone as against when administered in combination with other agents. The aim of this study is to understand the effects of addition of combination agents on the pharmacokinetics of a new, investigational, cyclin dependent kinase inhibitor anti-cancer drug (Compound A) using population pharmacokinetic (pop-PK) analysis. Integrated pop-PK analysis of data obtained from multiple phase I/II studies of Compound A, given alone or in combination with other agents. A two compartmental model was found suitable to explain the pharmacokinetics of Compound A. No statistically significant influence of patient covariates or combination agents on the pharmacokinetic parameters of the central compartment was detected up to a significance level of 0.01. Model evaluation showed that the parameter estimates are stable and that the variability in the data was well reproduced by the model. This study represents the first time that a pop-PK analysis was performed in India for a ta...Continue Reading

References

Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eunice L KwakBruce Chabner
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aurélie PetainUNKNOWN Innovative Therapies with Children with Cancer European consortium
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Mar 12, 2011·British Journal of Clinical Pharmacology·Lokesh JainWilliam D Figg
Jul 19, 2011·Journal of the National Cancer Institute·Rachel W HumphreyDrew M Pardoll

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Citations

May 16, 2012·Surgical Oncology Clinics of North America·Brandon K Isariyawongse, Michael W Kattan

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