Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers

Malaria Journal
Sofia BirgerssonJoel Tarning

Abstract

Artemisinin-based combination therapy is recommended as first-line anti-malarial treatment worldwide. A combination of artemisinin with the long acting drug piperaquine has shown high efficacy and tolerability in patients with uncomplicated Plasmodium falciparum infections. The aim of this study was to characterize the population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers after two different dose sizes, formulations and in a combination with piperaquine. A secondary aim was to compare two different methods for the evaluation of bioequivalence of the formulations. Fifteen subjects received four different dose regimens of a single dose of artemisinin as a conventional formulation (160 and 500 mg) and as a micronized test formulation (160 mg alone and in combination with piperaquine phosphate, 360 mg) with a washout period of 3 weeks between each period (i.e. four-way cross-over). Venous plasma samples were collected frequently up to 12 h after dose in each period. Artemisinin was quantified in plasma using liquid chromatography coupled with tandem mass spectrometry. A nonlinear mixed-effects modelling approach was utilized to evaluate the population pharmacokinetic properties of the drug and t...Continue Reading

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Citations

Sep 20, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jing WangYufeng Ding
Dec 2, 2020·The Science of the Total Environment·Ives Charlie-SilvaGuilherme Malafaia
Dec 22, 2017·Emerging Topics in Life Sciences·Colin J Sutherland
Mar 30, 2021·Frontiers in Pharmacology·Charlotte KernFelix Hammann
Dec 1, 2019·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·B M GruessnerP J Weathers
Jun 9, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Juan GüizaJosé L Vega

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Methods Mentioned

BETA
blood collection

Software Mentioned

Pearl
R
Xpose
- NONMEM ( PsN )
NONMEM
Pirana
Berkeley Madonna

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