Population pharmacokinetics of ceftriaxone and pharmacodynamic considerations in haemodialysed patients.

Clinical Pharmacokinetics
Nicolas SimonSaïk Urien

Abstract

To determine the pharmacokinetic parameters of ceftriaxone following an infusion in haemodialysed outpatients and to use these parameters for an optimisation of dosing based on pharmacodynamic indices. Fifty haemodialysed patients were enrolled in a single-centre, prospective, open-label study. They received short intravenous infusions of ceftriaxone 1 or 2 g every 48 hours for bronchopneumonia immediately after the dialysis session. Total plasma concentrations of ceftriaxone were analysed with a population pharmacokinetic approach using nonlinear mixed-effects modelling. Free drug concentrations were derived from published binding parameters in order to estimate the time when they exceed the minimum inhibitory concentration (MIC). The pharmacokinetics were best described by a two-compartment model. None of the covariates tested (age, bodyweight, height, sex, body mass index, albumin) influenced the pharmacokinetic parameters. The estimated population pharmacokinetic parameters (interindividual variability [percentage of coefficient of variation]) were clearance 0.36 L/h (48%), volume of distribution of the central compartment 4.53 L (47%), intercompartmental clearance 10.8 L/h and volume of distribution of the peripheral compa...Continue Reading

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Citations

Aug 4, 2009·European Journal of Drug Metabolism and Pharmacokinetics·Satofumi IidaMasahiro Hayashi
Aug 5, 2010·Wiener klinische Wochenschrift·Sebastian MausBertram Hartmann
May 7, 2011·British Journal of Clinical Pharmacology·Denis GarotChantal Le Guellec
Aug 2, 2012·Thérapie·Eric DaillyDanièle Bentué-Ferrer
Oct 28, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Koji GotoHiroki Itoh
Jun 27, 2019·Antimicrobial Agents and Chemotherapy·Matthieu GrégoireNathalie Asseray
Jun 11, 2019·Expert Review of Anti-infective Therapy·João Paulo TellesFelipe Francisco Tuon

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