Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand.

Antimicrobial Agents and Chemotherapy
Joel TarningNicholas J White

Abstract

The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-piperaquine were characterized. Piperaquine pharmacokinetics in 98 Burmese and Karen patients aged 3 to 55 years were described by a two-compartment disposition model with first-order absorption and interindividual random variability on all parameters and were similar with the three- and four-dose regimens. Children had a lower body weight-normalized oral clearance than adults, resulting in longer terminal elimination half-lives and higher total exposure to piperaquine (area under the concentration-time curve from 0 to 63 days [AUC day 0-63]). However, children had lower plasma concentrations in the therapeutically relevant posttreatment prophylactic period (AUC day 3-20) because of smaller body weight-normalized central volumes of distribution and shorter distribution half-lives. Our data lend further support to a simplified once-daily treatment regimen to improve treatment adherence and efficacy and indicate that weight-adjusted piperaquine doses in children may need to be higher than in adults.

References

Jul 1, 1989·British Journal of Clinical Pharmacology·K A MiltonA M Breckenridge
Jan 1, 1994·British Journal of Clinical Pharmacology·P E RolanJ Posner
Mar 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·C LuxemburgerF Nosten
Jan 1, 1997·European Journal of Clinical Pharmacology·C CrevoisierC Kleinbloesem
Apr 9, 1999·Computer Methods and Programs in Biomedicine·E N Jonsson, M O Karlsson
Jul 27, 2001·Journal of Pharmacokinetics and Pharmacodynamics·U WählbyM O Karlsson
Jan 5, 2002·Journal of Pharmacokinetics and Pharmacodynamics·S L Beal
Mar 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gary GinsbergRob Goble
Nov 27, 2002·Journal of Pharmacokinetics and Pharmacodynamics·Ulrika WählbyMats O Karlsson
Dec 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mey Bouth DenisDoung Socheat
Dec 18, 2003·British Journal of Clinical Pharmacology·Harin KarunajeewaTimothy M E Davis
Mar 5, 2004·British Journal of Clinical Pharmacology·Te-Yu HungDoung Socheat
May 19, 2005·Computer Methods and Programs in Biomedicine·Justin J Wilkins
May 21, 2005·Journal of Pharmaceutical and Biomedical Analysis·N LindegårdhN P J Day
May 27, 2005·Antimicrobial Agents and Chemotherapy·Ing-Kye SimKenneth F Ilett
Jul 20, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth A AshleyFrancois Nosten
Nov 24, 2005·Antimicrobial Agents and Chemotherapy·Joel TarningNicholas J White
Mar 30, 2006·European Journal of Clinical Pharmacology·Daniel RöshammarMichael Ashton
Aug 25, 2006·Clinical Pharmacokinetics·Trevor N JohnsonGeoffrey T Tucker
Sep 8, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·J TarningN Lindegårdh
Mar 17, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A R HasugianR N Price

❮ Previous
Next ❯

Citations

Mar 20, 2010·European Journal of Clinical Pharmacology·Elizabeth A AshleyFrançois Nosten
Apr 22, 2009·Antimicrobial Agents and Chemotherapy·Brioni R MooreKevin T Batty
Jun 29, 2011·Antimicrobial Agents and Chemotherapy·Anna AnnerbergFrançois Nosten
Feb 15, 2012·Antimicrobial Agents and Chemotherapy·Kevin T BattyTimothy M E Davis
Jul 6, 2012·The American Journal of Tropical Medicine and Hygiene·Ishag AdamFrançois Nosten
Mar 14, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joaniter I NankabirwaMoses R Kamya
May 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Humphrey WanziraGrant Dorsey
Oct 31, 2014·Science Translational Medicine·Martin BergstrandJoel Tarning
Apr 2, 2015·Expert Review of Anti-infective Therapy·Lorenz von Seidlein, Arjen Dondorp
Oct 30, 2010·Trends in Parasitology·Ronan JambouMilijaona Randrianarivelojosia
Jun 1, 2010·The Lancet Infectious Diseases·Nicholas M DouglasRic N Price
Nov 21, 2013·British Journal of Clinical Pharmacology·Kashyap PatelCarl M Kirkpatrick
May 27, 2008·Toxicology·Kevin T BattyTimothy M E Davis
Mar 21, 2008·Trends in Parasitology·Nicholas J WhiteJulie Simpson
Aug 22, 2015·Clinical Drug Investigation·Stephanie E ReuterSilvia Pace

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.