Population pharmacokinetics of tamsulosin hydrochloride in paediatric patients with neuropathic and non-neuropathic bladder.

British Journal of Clinical Pharmacology
Yasuhiro TsudaShun Higuchi

Abstract

Tamsulosin is available on prescription as a modified release capsule in the US (Flomax), and in most European countries for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). The pharmacokinetics of tamsulosin hydrochloride (HCl) have been extensively studied in adults, but no pharmacokinetic data for paediatrics have been published to date. A population pharmacokinetic model of tamsulosin HCl was developed in paediatric patients. Covariate analysis revealed that body weight and alpha(1)-acid glycoprotein influenced both the apparent clearance and the apparent volume of distribution. This study confirms that there is no major difference in the pharmacokinetics of tamsulosin HCl between paediatrics (age range 2-16 years) and adults when the effect of body weight is taken into consideration. The main objective of this study was to characterize the population pharmacokinetics of tamsulosin hydrochloride (HCl) in paediatric patients with neuropathic and non-neuropathic bladder. A secondary objective was to compare the pharmacokinetics in paediatric patients and adults. Tamsulosin HCl plasma concentrations in 1082 plasma samples from 189 paediatric patients (age range 2-16 years) were analyzed with NONME...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Dec 16, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H KamimuraL F Chasseaud
Apr 9, 1999·Computer Methods and Programs in Biomedicine·E N Jonsson, M O Karlsson
Jul 27, 2001·Journal of Pharmacokinetics and Pharmacodynamics·U WählbyM O Karlsson
Mar 16, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gary GinsbergRob Goble
Mar 22, 2002·Clinical Pharmacology and Therapeutics·Leslie Z Benet, Betty-ann Hoener
Sep 12, 2002·Clinical Pharmacokinetics·Jane Alcorn, Patrick J McNamara
Sep 23, 2003·The Journal of Urology·Paul AbramsUNKNOWN European Tamsulosin Neurogenic Lower Urinary Tract Dysfunction Study Group
Nov 25, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Hidehiro KakizakiTomohiko Koyanagi
Jan 13, 2004·Clinical Pharmacokinetics·Jean-Xavier Mazoit, Bernard J Dalens
Dec 16, 2005·The AAPS Journal·Bernd MeibohmJeffrey S Barrett
Feb 9, 2006·British Journal of Pharmacology·Martin C Michel, Wim Vrydag
Jun 30, 2006·European Journal of Pediatrics·Brian J AndersonNicholas H G Holford
Jun 16, 2007·Clinical Pharmacology and Therapeutics·M O Karlsson, R M Savic
Oct 5, 2007·Annual Review of Pharmacology and Toxicology·B J Anderson, N H G Holford
Jan 17, 2008·Journal of Pharmacokinetics and Pharmacodynamics·Teun M PostMeindert Danhof
Aug 4, 2009·The AAPS Journal·Radojka M Savic, Mats O Karlsson

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Citations

May 8, 2013·Journal of Pharmaceutical Sciences·Nick HolfordBrian Anderson
Mar 22, 2016·International Journal of Environmental Research and Public Health·Paweł KrollPrzemysław Mańkowski
Feb 17, 2017·Journal of Investigative Medicine High Impact Case Reports·Mayur D ModyVamsi K Kota
Jun 10, 2011·Current Opinion in Urology

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