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Population Pharmacokinetics of Teicoplanin in Preterm and Term Neonates: is it Time for a New Dosing Regimen?

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

A KontouE Roilides

Abstract

OBJECTIVES: To develop a population pharmacokinetic (PK) model in order to evaluate currently recommended dosing regimen in term and preterm neonates.METHODS: By using optimal design approach, a prospective PK study was designed and implemented in 60 neonates with post-menstrual age of ...read more

Mentioned in this Paper

Creatinine Renal Clearance Decreased
Hospitals, High-Volume
Dose Regimen
Plasma
Simulation
Evaluation
Pharmacodynamics
Drug Kinetics
Treatment Protocols
High Performance Liquid Chromatography Mass Spectrometry
2
Paper Details
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Population Pharmacokinetics of Teicoplanin in Preterm and Term Neonates: is it Time for a New Dosing Regimen?

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

A KontouE Roilides

PMID: 31932366

DOI: 10.1128/aac.01971-19

Abstract

OBJECTIVES: To develop a population pharmacokinetic (PK) model in order to evaluate currently recommended dosing regimen in term and preterm neonates.METHODS: By using optimal design approach, a prospective PK study was designed and implemented in 60 neonates with post-menstrual age of ...read more

Mentioned in this Paper

Creatinine Renal Clearance Decreased
Hospitals, High-Volume
Dose Regimen
Plasma
Simulation
Evaluation
Pharmacodynamics
Drug Kinetics
Treatment Protocols
High Performance Liquid Chromatography Mass Spectrometry
2

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Vitamin K-dependent carboxylases generate gamma-carboxyglutamic acids with malonate moieties by modifying glutamate residues in vitamin K-dependent proteins. This feed focuses on cellular mechanisms regulated by vitamin K-dependent carboxylases.

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