Population Pharmacokinetics of Vancomycin in Chinese ICU Neonates: Initial Dosage Recommendations

Frontiers in Pharmacology
Zhi-Ling LiHua-Jun Sun

Abstract

The main goal of our study was to characterize the population pharmacokinetics of vancomycin in critically ill Chinese neonates to develop a pharmacokinetic model and investigate factors that have significant influences on the pharmacokinetics of vancomycin in this population. The study population consisted of 80 neonates in the neonatal intensive care unit (ICU) from which 165 trough and peak concentrations of vancomycin were obtained. Nonlinear mixed effect modeling was used to develop a population pharmacokinetic model for vancomycin. The stability and predictive ability of the final model were evaluated based on diagnostic plots, normalized prediction distribution errors and the bootstrap method. Serum creatinine (Scr) and body weight were significant covariates on the clearance of vancomycin. The average clearance was 0.309 L/h for a neonate with Scr of 23.3 μmol/L and body weight of 2.9 kg. No obvious ethnic differences in the clearance of vancomycin were found relative to the earlier studies of Caucasian neonates. Moreover, the established model indicated that in patients with a greater renal clearance status, especially Scr < 15 μmol/L, current guideline recommendations would likely not achieve therapeutic area under th...Continue Reading

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Citations

Aug 2, 2020·Journal of Clinical Pharmacy and Therapeutics·Aijie GuoHongjuan Xie
Dec 16, 2020·Antimicrobial Agents and Chemotherapy·Hiroshi SasanoKazuhiko Hanada
Mar 19, 2021·Scientific Reports·Soon Min LeeMin Jung Chang
May 19, 2021·Clinical Pharmacokinetics·Erin ChungWinnie Seto
Jun 23, 2021·European Journal of Drug Metabolism and Pharmacokinetics·Kannan SridharanMwila Mulubwa
Dec 4, 2021·Frontiers in Pharmacology·Muhammad Muaaz MunirMuhammad Usman

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Methods Mentioned

BETA
PMA

Software Mentioned

Pirana
NONMEM
R

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