Population pharmacokinetics of vancomycin in patients with external ventricular drain-associated ventriculitis.

British Journal of Clinical Pharmacology
Kris Oliver JalusicMichael Hessler

Abstract

To determine the distribution of vancomycin into the cerebrospinal fluid (CSF) in patients with external ventricular drain (EVD)-associated ventriculitis, the pharmacokinetics of vancomycin were evaluated and covariate relationships explored. For the population pharmacokinetic model patients were recruited in a neurocritical care unit at the University Hospital of Muenster in the period between January 2014 and June 2015. All patients had a clinical evidence of EVD-associated ventriculitis. Population pharmacokinetic analysis of vancomycin was performed using NONMEM. A total of 184 blood and 133 CSF samples were collected from 29 patients. The final population pharmacokinetic model is a three-compartment model with linear elimination. Creatinine clearance (ClCr ) and CSF-lactate were detected as significant covariates, showing that the total vancomycin plasma clearance (Cl) depends on ClCr and furthermore the clearance (Cldif ) between the central and CSF compartment correlates with CSF lactate concentration. Based on the final model, the following values were estimated by NONMEM: Cl = 5.15 L/h, Q (intercompartmental clearance) = 3.31 L/h, Cldif  = 0.0031 L/h, Vcentral  = 42.1 L, VCSF  = 0.32 L and the value of Vperipheral was ...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Dec 1, 1991·Antimicrobial Agents and Chemotherapy·P F ViladrichJ Ariza
Apr 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·S VozehD R Stanski
Jul 1, 1986·Clinical Pharmacokinetics·G R MatzkeD R Guay
Jun 1, 1981·The Journal of Infection·G D CurtisD S Tompkins
Jan 1, 1993·Journal of Inherited Metabolic Disease·M B Segal
Oct 2, 1998·Pharmaceutical Research·E N Jonsson, M O Karlsson
Aug 17, 2002·Neurosurgery·Alan P LozierE Sander Connolly
Nov 25, 2004·Neuroscience·P D BrownI D Millar
Jul 19, 2005·Computer Methods and Programs in Biomedicine·Lars LindbomNiclas Jonsson
Aug 27, 2005·British Journal of Clinical Pharmacology·Hussain Mulla, Suneel Pooboni
Dec 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J Rybak
Sep 9, 2006·Journal of Clinical Pharmacy and Therapeutics·P Llopis-Salvia, N V Jiménez-Torres
Dec 14, 2006·Intensive Care Medicine·Maria del Mar Fernández de Gatta GarciaAmparo Sánchez Navarro
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Damien RicardDidier Dreyfuss
May 20, 2009·The AAPS Journal·Martin Bergstrand, Mats O Karlsson
Oct 31, 2009·Burns : Journal of the International Society for Burn Injuries·Michael DoltonAndrew J McLachlan
Jul 24, 2010·International Journal of Clinical Pharmacology and Therapeutics·J L SánchezJ M Cornejo-Bravo
Jul 27, 2010·British Journal of Clinical Pharmacology·Natalia RevillaMaría Del Mar Fernández de Gatta
Nov 5, 2010·Anesthesia and Analgesia·Andrew UdyJeffrey Lipman
Mar 16, 2011·Antimicrobial Agents and Chemotherapy·Jason A RobertsJeffrey Lipman
Jan 27, 2012·Journal of Neurology·Ben L C WrightAlexandra J Sinclair
Aug 29, 2013·Critical Care Medicine·Maria ChatziEpaminondas Zakynthinos
Nov 25, 2014·Critical Care : the Official Journal of the Critical Care Forum·Katia DonadelloFabio Silvio Taccone
Mar 13, 2015·Neurocritical Care·Casey C MayAaron M Cook
Aug 5, 2015·Journal of Pharmaceutical Sciences·Xingang LiZhigang Zhao
Oct 21, 2016·The Journal of Hospital Infection·H HumphreysUNKNOWN Healthcare Infection Society Working Party on Neurosurgical Infections
Feb 17, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelJoseph R Zunt
May 22, 2017·Clinical Pharmacokinetics·Jessica E BeachMary H H Ensom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.