Population relationships in the Mediterranean revealed by autosomal genetic data (Alu and Alu/STR compound systems)

American Journal of Physical Anthropology
Emili González-PérezP Moral

Abstract

The variation of 18 Alu polymorphisms and 3 linked STRs was determined in 1,831 individuals from 15 Mediterranean populations to analyze the relationships between human groups in this geographical region and provide a complementary perspective to information from studies based on uniparental markers. Patterns of population diversity revealed by the two kinds of markers examined were different from one another, likely in relation to their different mutation rates. Therefore, while the Alu biallelic variation underlies general heterogeneity throughout the whole Mediterranean region, the combined use of Alu and STR points to a considerable genetic differentiation between the two Mediterranean shores, presumably strengthened by a considerable sub-Saharan African genetic contribution in North Africa (around 13% calculated from Alu markers). Gene flow analysis confirms the permeability of the Sahara to human passage along with the existence of trans-Mediterranean interchanges. Two specific Alu/STR combinations-CD4 110(-) and DM 107(-)-detected in all North African samples, the Iberian Peninsula, Greece, Turkey, and some Mediterranean islands suggest an ancient genetic background of current Mediterranean peoples.

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Citations

Jan 12, 2010·Annals of Human Genetics·Georgios AthanasiadisPedro Moral
Aug 5, 2010·BMC Evolutionary Biology·Mathias CurratAlicia Sanchez-Mazas
Sep 21, 2011·Genetics and Molecular Biology·Wifak El MoncerHassen Chaabani
Jun 25, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Miguel M Álvarez-ÁlvarezPedro Moral
Jan 18, 2017·European Journal of Human Genetics : EJHG·Miguel M Álvarez-ÁlvarezGeorgios Athanasiadis
May 16, 2017·Annals of Human Biology·Martina ČížkováViktor Černý
Oct 1, 2010·Journal of Human Genetics·Wifak El MoncerHassen Chaabani
Sep 6, 2013·Journal of Human Genetics·Georgios Athanasiadis, Pedro Moral
Nov 24, 2011·Genetic Testing and Molecular Biomarkers·Raoudha BahriHassen Chaabani
Apr 4, 2019·Annals of Human Biology·Amine Abdeli, Traki Benhassine
Sep 22, 2010·Annals of Human Biology·Maria GaibarAna Fernández-Santander
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Feb 14, 2012·Annals of Human Biology·Ana Fernández-SantanderMaría Gaibar
Mar 28, 2019·Scientific Reports·María SaizLuis Javier Martinez-Gonzalez

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