Population-representative incidence of drug-induced acute liver failure based on an analysis of an integrated health care system

Gastroenterology
David GoldbergVincent Lo Re

Abstract

Medications are a major cause of acute liver failure (ALF) in the United States, but no population-based studies have evaluated the incidence of ALF from drug-induced liver injury. We aimed to determine the incidence and outcomes of drug-induced ALF in an integrated health care system that approximates a population-based cohort. We performed a retrospective cohort study using data from the Kaiser Permanente Northern California (KPNC) health care system between January 1, 2004, and December 31, 2010. We included all KPNC members age 18 years and older with 6 months or more of membership and hospitalization for potential ALF. The primary outcome was drug-induced ALF (defined as coagulopathy and hepatic encephalopathy without underlying chronic liver disease), determined by hepatologists who reviewed medical records of all KPNC members with inpatient diagnostic and laboratory criteria suggesting potential ALF. Among 5,484,224 KPNC members between 2004 and 2010, 669 had inpatient diagnostic and laboratory criteria indicating potential ALF. After medical record review, 62 (9.3%) were categorized as having definite or possible ALF, and 32 (51.6%) had a drug-induced etiology (27 definite, 5 possible). Acetaminophen was implicated in 1...Continue Reading

References

Oct 1, 1994·Digestive Diseases and Sciences·F J FarrellC O Esquivel
Jan 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·F V SchiodtW M Lee
Jan 22, 2000·Annals of Internal Medicine·L M FormanR H Diamond
Dec 18, 2002·Annals of Internal Medicine·George OstapowiczUNKNOWN U.S. Acute Liver Failure Study Group
Jul 26, 2003·Clinics in Liver Disease·Michael Thiim, Lawrence S Friedman
Aug 2, 2003·The New England Journal of Medicine·William M Lee
Oct 3, 2003·Seminars in Liver Disease·William M Lee
Dec 18, 2003·Annals of Internal Medicine·William D Carey
Sep 25, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mark W RussoPaul Watkins
Oct 7, 2004·Journal of Hepatology·Diego VerganiUNKNOWN International Autoimmune Hepatitis Group
Nov 2, 2004·BMJ : British Medical Journal·Keith HawtonKenneth Simpson
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie PolsonUNKNOWN American Association for the Study of Liver Disease
Jul 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Einar Björnsson, Rolf Olsson
Aug 9, 2005·Gastroenterology·Raúl J AndradeUNKNOWN Spanish Group for the Study of Drug-Induced Liver Disease
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anne M LarsonUNKNOWN Acute Liver Failure Study Group
Feb 14, 2006·Seminars in Oncology·Justin FloydMichael C Perry
Feb 17, 2006·The New England Journal of Medicine·Victor J Navarro, John R Senior
May 6, 2006·The Journal of Allergy and Clinical Immunology·Michael SchatzE Francis Cook
Mar 21, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Angels EscorsellUNKNOWN Spanish Group for the Study of Acute Liver Failure
Jul 5, 2007·The American Journal of Gastroenterology·William A BowerBeth P Bell
Jul 31, 2007·The American Journal of Gastroenterology·Kartik JinjuvadiaRobert J Fontana
Aug 29, 2007·Clinics in Liver Disease·John R Senior
Sep 18, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K L NashW J H Griffiths
Nov 22, 2007·Acta Haematologica·Jee Hyun KongChu-Myong Seong
Mar 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·William M LeeJay H Hoofnagle
Jan 10, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Robert J FontanaUNKNOWN DILIN Study Group
Jan 29, 2009·The American Journal of Gastroenterology·Loren LaineChristoper P Cannon
Jul 1, 2007·Current Opinion in HIV and AIDS·Martin Vogel, Jürgen K Rockstroh
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C RockeyUNKNOWN US Drug-Induced Liver Injury Network
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael P MannsUNKNOWN American Association for the Study of Liver Diseases
Sep 8, 2010·Alimentary Pharmacology & Therapeutics·R VuppalanchiUNKNOWN Drug-Induced Liver Injury Network (DILIN)
Oct 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adrian ReubenUNKNOWN Acute Liver Failure Study Group
Dec 24, 2010·The Journal of Nutrition·Regan L BaileyMary Frances Picciano
Feb 26, 2011·Journal of Hepatology·Miren García-CortésRaúl J Andrade
May 6, 2011·Clinical Pharmacology and Therapeutics·G P AithalA K Daly
Mar 1, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Johannes HademUNKNOWN Acute Liver Failure Study Group Germany
Jun 20, 2012·Annals of Internal Medicine·Naga ChalasaniJay H Hoofnagle
Mar 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jay H HoofnagleVictor J Navarro
Jan 16, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Manuel MendizabalMarcelo O Silva
Apr 8, 2014·Gastroenterology·Mercedes Robles-DiazUNKNOWN Safer and Faster Evidence-based Translation Consortium
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Victor J NavarroRaj Vuppalanchi

❮ Previous
Next ❯

Citations

Nov 26, 2015·The American Journal of Medicine·Vincent Lo ReDouglas A Corley
Jan 29, 2016·Expert Opinion on Drug Metabolism & Toxicology·Raúl J AndradeMaría Isabel Lucena
Feb 18, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vincent Lo ReDouglas A Corley
Jul 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vincent Lo ReDouglas A Corley
Mar 18, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Xiaoqing Guo, Nan Mei
Apr 6, 2016·The American Journal of Gastroenterology·Luke HillmanDaniel Ganger
Apr 20, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rolf Teschke, Gaby Danan
May 5, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Philip SargesJames H Lewis
Apr 14, 2015·Pharmacoepidemiology and Drug Safety·Vincent Lo ReDouglas A Corley
Mar 16, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christine M HuntArie Regev
Feb 19, 2017·Heart·Tatjana S Potpara, Gregory Yh Lip
Jan 13, 2018·Expert Review of Gastroenterology & Hepatology·Ran WangXiaozhong Guo
Sep 13, 2017·International Journal of Molecular Sciences·Marcial SebodeAnsgar W Lohse
Mar 27, 2018·Journal of Clinical and Translational Hepatology·Jing Jing, Rolf Teschke
Sep 29, 2018·The Journal of Pathology·Miguel E ZoubekFrancisco J Cubero
Apr 6, 2019·Artificial Organs·Yimin Zhang, Lanjuan Li
Mar 23, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mussarat N RahimMichael A Heneghan
Feb 16, 2019·Current Drug Safety·Carla Stefania ColaciFernando Bessone
Jul 19, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Sabine WeberAlexander L Gerbes
Aug 24, 2019·Nature Reviews. Disease Primers·Raul J AndradeGuruprasad P Aithal
Jul 15, 2015·World Journal of Hepatology·Emanuel Raschi, Fabrizio De Ponti
Mar 11, 2020·Archives of Toxicology·Eva GijbelsMathieu Vinken
Aug 28, 2020·Archives of Toxicology·Miren Garcia-CortesRaúl J Andrade
May 5, 2017·Open Forum Infectious Diseases·Charitha GowdaVincent Lo Re
May 31, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Maricruz VegaUNKNOWN Drug Induced Liver Injury Network (DILIN)
Apr 27, 2017·World Journal of Hepatology·Tamara AlempijevicTomica Milosavljevic
Dec 21, 2019·World Journal of Gastroenterology : WJG·Priya Grewal, Jawad Ahmad
Jun 27, 2020·Frontline Gastroenterology·Nelia HernandezFernando Bessone
Sep 18, 2015·World Journal of Hepatology·Evangelos Stournaras, Konstantinos Tziomalos
Nov 23, 2019·Clinics in Liver Disease·Maneerat Chayanupatkul, Thomas D Schiano
Feb 11, 2020·Deutsches Ärzteblatt International·Nina WeilerMartin-Walter Welker
Feb 27, 2021·Abdominal Radiology·Shuchi K Rodgers, Mindy M Horrow
Jun 3, 2021·International Journal of Molecular Sciences·Andrés TabernillaMathieu Vinken
Jun 28, 2019·Chemical Research in Toxicology·Vânia Vilas-BoasMathieu Vinken
Nov 27, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Guruprasad P Aithal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Ophthalmic Epidemiology
Tisha Prabriputaloong StanzelDavid C Gritz
Cephalalgia : an International Journal of Headache
Amy A GelfandAlice Pressman
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
A Obaid ShakilJorge Rakela
© 2022 Meta ULC. All rights reserved