Population-specific material properties of the implantation site for transcatheter aortic valve replacement finite element simulations

Journal of Biomechanics
Giorgia M BosiSilvia Schievano

Abstract

Patient-specific computational models are an established tool to support device development and test under clinically relevant boundary conditions. Potentially, such models could be used to aid the clinical decision-making process for percutaneous valve selection; however, their adoption in clinical practice is still limited to individual cases. To be fully informative, they should include patient-specific data on both anatomy and mechanics of the implantation site. In this work, fourteen patient-specific computational models for transcatheter aortic valve replacement (TAVR) with balloon-expandable Sapien XT devices were retrospectively developed to tune the material parameters of the implantation site mechanical model for the average TAVR population. Pre-procedural computed tomography (CT) images were post-processed to create the 3D patient-specific anatomy of the implantation site. Balloon valvuloplasty and device deployment were simulated with finite element (FE) analysis. Valve leaflets and aortic root were modelled as linear elastic materials, while calcification as elastoplastic. Material properties were initially selected from literature; then, a statistical analysis was designed to investigate the effect of each implant...Continue Reading

Citations

Oct 16, 2018·Expert Review of Medical Devices·Oren M RotmanDanny Bluestein
Nov 22, 2018·Biomechanics and Modeling in Mechanobiology·Matteo BianchiDanny Bluestein
Jul 17, 2019·Cardiovascular Engineering and Technology·Giulia LuraghiJose Felix Rodriguez Matas
Oct 2, 2019·Biomechanics and Modeling in Mechanobiology·Alessandro BorghiSilvia Schievano
Sep 1, 2019·Biomechanics and Modeling in Mechanobiology·Halit YaakobovichGil Marom
Jun 15, 2019·Cardiovascular Engineering and Technology·Giorgia RocatelloPeter Mortier
Apr 20, 2018·Frontiers in Cardiovascular Medicine·Giorgia Maria BosiGaetano Burriesci
Jun 20, 2020·Scientific Reports·Giorgia M BosiSilvia Schievano
Nov 18, 2020·Expert Review of Cardiovascular Therapy·Giulia LuraghiFrancesco Migliavacca
Jun 16, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Dong QiuAli N Azadani

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Matlab
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Abaqus

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