Abstract
Single nucleotide polymorphisms (SNPs) in the P2 promoter region of HNF4A were originally shown to be associated with predisposition for type 2 diabetes in Finnish, Ashkenazi, and, more recently, Scandinavian populations, but they generated conflicting results in additional populations. We aimed to investigate whether data from a large-scale mapping approach would replicate this association in novel Ashkenazi samples and in U.K. populations and whether these data would allow us to refine the association signal. Using a dense linkage disequilibrium map of 20q, we selected SNPs from a 10-Mb interval centered on HNF4A. In a staged approach, we first typed 4,608 SNPs in case-control populations from four U.K. populations and an Ashkenazi population (n = 2,516). In phase 2, a subset of 763 SNPs was genotyped in 2,513 additional samples from the same populations. Combined analysis of both phases demonstrated association between HNF4A P2 SNPs (rs1884613 and rs2144908) and type 2 diabetes in the Ashkenazim (n = 991; P < 1.6 x 10(-6)). Importantly, these associations are significant in a subset of Ashkenazi samples (n = 531) not previously tested for association with P2 SNPs (odds ratio [OR] approximately 1.7; P < 0.002), thus providing...Continue Reading
References
Mar 15, 2001·Diabetes·M A PermuttB Glaser
Aug 3, 2001·American Journal of Human Genetics·S WiltshireM I McCarthy
Apr 30, 2003·Diabetes·Simon M S MitchellAndrew T Hattersley
Jun 6, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·K R OwenA T Hattersley
Jul 17, 2003·Clinical Endocrinology·Michael N WeedonTimothy M Frayling
Oct 14, 2003·PLoS Biology·Inês BarrosoNicholas J Wareham
Dec 25, 2003·American Journal of Epidemiology·Anne-Helen HardingNicholas J Wareham
Jan 22, 2004·Human Molecular Genetics·Xiayi KePanos Deloukas
Mar 30, 2004·Diabetes·Latisha D Love-GregoryM Alan Permutt
Mar 30, 2004·Diabetes·Kaisa SilanderFrancis S Collins
Sep 2, 2004·Cold Spring Harbor Symposia on Quantitative Biology·J B FanM S Chee
Oct 27, 2004·Diabetes·Michael N WeedonTimothy M Frayling
Nov 25, 2004·Diabetes·Coleen M DamcottAlan R Shuldiner
Mar 1, 2005·Diabetes·Wendy WincklerDavid Altshuler
Mar 1, 2005·Diabetologia·S K HansenT Hansen
Mar 1, 2005·Diabetologia·M VaxillaireP Froguel
Mar 29, 2005·Diabetes·Allison M BagwellDonald W Bowden
Sep 28, 2005·Diabetes·Yunhua Li MullerLeslie J Baier
Mar 9, 2006·Diabetes & Metabolism·K WanicJ Sieradzki
Apr 29, 2006·Diabetes·Kazuo HaraTakashi Kadowaki
May 30, 2006·Diabetes·Jakob EkTorben Hansen
Aug 29, 2006·Diabetes·Lori L BonnycastleFrancis S Collins
Sep 7, 2006·Human Genetics·Toshihito TanahashiMitsuo Itakura
Oct 19, 2006·PLoS Genetics·Chris C A SpencerGil McVean
Nov 30, 2006·Diabetes·Neil B RudermanMeghan Kelly
Jan 30, 2007·Diabetes·Donna M LehmanMichael P Stern
Sep 11, 2007·Diabetes·Stefan JohanssonPål Rasmus Njølstad
Citations
Feb 15, 2011·Inflammatory Bowel Diseases·Alexandra I Thompson, Charlie W Lees
Oct 11, 2011·Biochemical Genetics·Riyadh Saif-AliWan Zurinah Wan Ngah
Sep 21, 2012·Current Diabetes Reports·Yoon Shin ChoChu Won Nho
Aug 24, 2012·Genes and Immunity·V MarcilE Levy
Aug 5, 2011·Journal of Human Genetics·Sreenivas ChavaliDwaipayan Bharadwaj
Dec 14, 2011·Nature Genetics·Yoon Shin ChoMark Seielstad
Nov 17, 2009·Nature Genetics·UNKNOWN UK IBD Genetics ConsortiumDavid P Strachan
Mar 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ionel SandoviciSusan E Ozanne
Apr 21, 2009·Human Molecular Genetics·Hélène ChoquetDavid Meyre
Dec 9, 2008·Genome Biology·Rong ChenAtul J Butte
Mar 8, 2012·PLoS Genetics·Buhm Han, Eleazar Eskin
Apr 3, 2010·PloS One·Rosalind J NeumanM Alan Permutt
Dec 23, 2011·PPAR Research·Yi ZhangYi Zhu
Jan 27, 2012·Journal of Human Genetics·Rubina TabassumDwaipayan Bharadwaj
Aug 13, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Suk-Kyun YangKyuyoung Song
Sep 15, 2009·Molecular Genetics and Metabolism·Silvia SookoianCarlos J Pirola
May 2, 2009·Diabetes Research and Clinical Practice·Stephanie-May RuchatPérusse Louis
May 1, 2009·Diabetes/metabolism Research and Reviews
Jan 26, 2013·Human Mutation·Kevin ColcloughSian Ellard
Sep 24, 2015·Iranian Journal of Pediatrics·Hossein MoravejOmid Aryani
Oct 29, 2014·Diabetes & Metabolism Journal·Min Jin GoBong-Jo Kim
May 14, 2011·American Journal of Human Genetics·Buhm Han, Eleazar Eskin
Apr 25, 2009·Diabetes·Inga ProkopenkoUNKNOWN International Type 2 Diabetes 1q Consortium
Feb 12, 2015·PloS One·Valérie MarcilEmile Levy
Jul 1, 2009·Nature Reviews. Endocrinology·Elliot S Stolerman, Jose C Florez
Apr 2, 2016·Endocrine Reviews·Yisheng Yang, Lawrence Chan
Mar 5, 2020·PLoS Genetics·Simon RioAlain Charcosset
Jan 20, 2016·Molecular Medicine Reports·Run MaWei Zhou
Jun 19, 2010·Experimental Biology and Medicine·Zhuo ChenHe Xu