Population structure of Neisseria gonorrhoeae based on whole genome data and its relationship with antibiotic resistance

PeerJ
Matthew N EzewudoTimothy D Read

Abstract

Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection (STI) of major importance. As a result of antibiotic resistance, there are now limited options for treating patients. We collected draft genome sequence data and associated metadata data on 76 N. gonorrhoeae strains from around the globe and searched for known determinants of antibiotics resistance within the strains. The population structure and evolutionary forces within the pathogen population were analyzed. Our results indicated a cosmopolitan gonoccocal population mainly made up of five subgroups. The estimated ratio of recombination to mutation (r/m = 2.2) from our data set indicates an appreciable level of recombination occurring in the population. Strains with resistance phenotypes to more recent antibiotics (azithromycin and cefixime) were mostly found in two of the five population subgroups.

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Datasets Mentioned

BETA
SRA099559
FA1090

Methods Mentioned

BETA
genotyping

Software Mentioned

MEGA
velvet assembler
BLAST
BLASTN
ABACUS
PHYLIP
mlstBLAST
MAUVE
Path
PAML

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