Population structure of Pseudomonas aeruginosa through a MLST approach and antibiotic resistance profiling of a Mexican clinical collection

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
F J Castañeda-MontesA E Escalante

Abstract

Pseudomonas aeruginosa is one of the most important pathogens worldwide. Population genetics studies have shown that the P. aeruginosa population has an epidemic structure with highly conserved clonal complexes. Nonetheless, epidemiological studies of P. aeruginosa have been historically absent or infrequent in developing countries, in which different medical treatments, conditions and infrastructure may have an impact in population dynamics and evolutionary outcomes, including antibiotic resistance profiles. In this study we contribute to fill this gap by analyzing 158 P. aeruginosa isolates from the most extensive nosocomial collection in Mexico City. We investigated the population genetic structure through a MLST approach together with a classical microbiology antibiotic resistance profiling, one of the associated concerns in the evolution of this pathogen. On the one hand, our results are in accordance with previous studies on the epidemic structure of P. aeruginosa, as well as the existence of three main phylogroups, that are not related to environmental parameters. On the other hand, antibiotic resistance profiles indicate higher prevalence in our sample of multi drug resistant (75.15%), extremely drug resistant (17.72%) ...Continue Reading

Citations

Sep 26, 2020·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Kasim AllelEduardo A Undurraga
Feb 9, 2021·Frontiers in Microbiology·Manuel Ii García-UlloaValeria Souza

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