PMID: 6976932Jan 1, 1981Paper

Population studies of the HLA-linked SB antigens

Immunogenetics
S ShawP L Smith

Abstract

Using allogeneic T-cell recognition we have previously defined five new histocompatibility antigens designated "SB" antigens. To standardize typing for these antigens, cryopreserved, primed lymphocytes are now used as standard reagents and a technique of cluster analysis has been modified to score typing results objectively. Two primed lymphocyte reagents are used to define each SB antigen; although derived from independent responder-stimulator combinations, the concordance between the reagents is good (r is greater than 0.86). The SB-antigen distribution in a population of 215 normal donors in consistent with Hardy-Weinberg equilibrium of alleles of a single locus. Estimated gene frequencies ranged between 3 percent (SB5) and 36 percent (SB4) with 31 percent blanks. Analysis of association between the SB antigens and A, B, DR antigens in 200 normal donors revealed that associations were generally weak with a few exceptions, in particular, the A1, B8, DR3, SB1 "haplotype" and also the B7, DR2, SB5 "haplotype".

References

Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·E J Yunis, D B Amos
Jun 16, 1967·Science·F H Bach, D B Amos

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Citations

Jan 1, 1983·Immunogenetics·P WernetG Pawelec
Jan 1, 1989·Immunogenetics·R Wank, H Grosse-Wilde
Jan 1, 1987·Immunogenetics·V LotteauD Charron
Oct 1, 1982·Human Immunology·F H Bach, N L Reinsmoen
Feb 1, 1983·Human Immunology·A ZeeviR J Duquesnoy
Nov 1, 1984·Human Immunology·N OhtaF H Bach
May 1, 1988·Human Immunology·J R RoweM J Sheehy
Jan 1, 1988·Human Immunology·M J SheehyL Jorgensen
Sep 1, 1990·Human Immunology·T W Sell, D D Eckels
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M Roux-DossetoJ L Strominger
Nov 1, 1982·The Journal of Experimental Medicine·C K HurleyJ D Capra
Apr 1, 1993·Scandinavian Journal of Immunology·J M Baisch, J D Capra
Oct 1, 1992·Tissue Antigens·V MantovaniG Gasbarrini
Aug 1, 1993·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·Z YaoE Albert
Oct 1, 1993·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·W M HowellD G Haegert
Apr 1, 1995·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·R W VaughanD G Williams
Mar 1, 1989·The Journal of Clinical Investigation·M J SheehyB S Nepom
May 1, 1982·Clinical Immunology and Immunopathology·R J DuquesnoyK Halim
Aug 1, 1989·Tissue Antigens·G Mueller-EckhardtC Mueller-Eckhardt
Sep 1, 1986·Arthritis and Rheumatism·R W HoffmanD N Glass

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