Population study of seroprevalence of antibodies against hepatitis A virus in the Community of Madrid, 2008-2009

Enfermedades infecciosas y microbiología clínica
Luis Garcia-ComasDolores Barranco

Abstract

Seroprevalence surveys enable the level of endemicity of hepatitis A (HAV) to be assessed. The aim of this study was to estimate the seroprevalence (SP) antibody against HAV by age group, and compare it with those obtained in previous surveys. Observational cross-sectional study. The target population consists of residents from 2 to 60 years old in the Community of Madrid. Two-stage cluster sampling was performed with stratification of first stage units. After signing the informed consent, a serum sample was extracted from each participant and sociodemographic data were collected by a questionnaire. SP antibodies to hepatitis A is 46.8% (95% CI 44.6 to 49.0). The SP increases with age. It is higher in the population from more endemic countries and people with less education and lower social class. In relation to the previous survey, SP increased in the population under 30 years old, and a decline after that age is observed. If only the autochthonous population and from countries with very low endemicity is observed, the increase is statistically significant in the 2-5 years age group. Our region has a very low level of endemicity thus, following the recommendations of WHO, vaccination should be targeted at specific risk groups.

References

Jan 8, 2005·Epidemiology and Infection·K H Jacobsen, J S Koopman
Jul 6, 2007·BMC Infectious Diseases·Angela DomínguezLluis Salleras
Nov 7, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·S FaillonF Dubos

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Citations

Nov 21, 2015·Enfermedades infecciosas y microbiología clínica·Alberto Arnedo-PenaFrancisco Pardo-Serrano
Mar 2, 2017·Medicine·Maria Filomena GalloneCinzia Germinario
Apr 1, 2018·Journal of Viral Hepatitis·P GodoyUNKNOWN Working Group for the Study of Hepatitis in Catalonia
May 27, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Alberto Hernández BustabadManuel Hernández-Guerra

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