Population susceptibility to a variant swine-origin influenza virus A(H3N2) in Vietnam, 2011-2012

Epidemiology and Infection
L N M HoaA Fox

Abstract

A reassortant swine-origin A(H3N2) virus (A/swine/BinhDuong/03-9/2010) was detected through swine surveillance programmes in southern Vietnam in 2010. This virus contains haemagglutinin and neuraminidase genes from a human A(H3N2) virus circulating around 2004-2006, and the internal genes from triple-reassortant swine influenza A viruses (IAVs). To assess population susceptibility to this virus we measured haemagglutination inhibiting (HI) titres to A/swine/BinhDuong/03-9/2010 and to seasonal A/Perth/16/2009 for 947 sera collected from urban and rural Vietnamese people during 2011-2012. Seroprevalence (HI ⩾ 40) was high and similar for both viruses, with 62·6% [95% confidence interval (CI) 59·4-65·7] against A/Perth/16/2009 and 54·6% (95% CI 51·4-57·8%) against A/swine/BinhDuong/03-9/2010, and no significant differences between urban and rural participants. Children aged <5 years lacked antibodies to the swine origin H3 virus despite high seroprevalence for A/Perth/16/2009. These results reveal vulnerability to infection to this contemporary swine IAV in children aged <5 years; however, cross-reactive immunity in adults would likely limit epidemic emergence potential.

References

Jun 19, 2010·Science·D VijaykrishnaY Guan
Jul 26, 2012·PLoS Pathogens·Justin LesslerDerek A T Cummings
May 23, 2015·Science·Tania Rabesandratana

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Citations

Nov 28, 2015·Influenza and Other Respiratory Viruses·Ellen FragaszyUNKNOWN Combating Swine Influenza (COSI) Consortium

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Methods Mentioned

BETA
serum collections

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