Population-wide administration of single dose rifampicin for leprosy prevention in isolated communities: a three year follow-up feasibility study in Indonesia

BMC Infectious Diseases
A TiwariJ H Richardus

Abstract

Indonesia ranking third in the world, regarding leprosy burden. Chemoprophylaxis is effective in reducing risk of developing leprosy among contacts. 'Blanket approach' is an operational strategy for leprosy post-exposure prophylaxis in which all members of an isolated community, high endemic for leprosy are screened and given a single dose of rifampicin (SDR) in the absence of signs and symptoms of leprosy. The objective is to assess the operational feasibility of a population-wide 'blanket' administration of SDR for leprosy prevention in isolated communities in a remote island. A prospective follow-up study was conducted in the year 2014, 2015 and 2016 in Lingat village of Selaru Island, Indonesia. During the first two visits, screening and SDR were provided, whereas only screening was conducted during the third visit. The demographic and clinical data were used for a descriptive analysis of the project coverage and leprosy epidemiology. During the first two visits, 1671 persons (88%) were screened, 1499 (79%) received SDR, and 213 (11%) were excluded based on the exclusion criteria. During the first two visits, 43 (2.6%) cases were diagnosed with leprosy with a rate of 2263 per 100,000 population. The prevalence was highest i...Continue Reading

References

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May 7, 2008·Public Health Reports·Brian H BennettMark Robson
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Oct 23, 2015·Parasites & Vectors·David J BlokJan Hendrik Richardus

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Citations

Nov 18, 2018·Tropical Medicine and Infectious Disease·Rie R Yotsu
Feb 27, 2020·Seminars in Immunopathology·Katharina RöltgenCharlotte Avanzi
Nov 2, 2020·The Lancet Global Health·Jan Hendrik RichardusPeter Steinmann

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