Porcine circovirus 2 inclusion bodies in pulmonary and renal epithelial cells

Veterinary Pathology
Y Y HuangE Simko

Abstract

Porcine circovirus 2 (PCV2) is the cause of postweaning multisystemic wasting syndrome (PMWS). The most common lesions of PMWS are lymphohistiocytic to granulomatous lymphadenitis, interstitial pneumonia and interstitial nephritis, with intracytoplasmic amphophilic botryoid inclusion bodies in macrophages. In addition to these typical changes, intracytoplasmic botryoid inclusion bodies were observed in bronchial, bronchial glandular, and renal tubular epithelium of several pigs from 4 different farms in Western and Eastern Canada. PCV2 inclusion bodies were demonstrated to be located in the cytoplasm of epithelial cells by immunohistochemical staining for PCV2 and cytokeratin antigens and by ultrastructural demonstration of viral particles in the inclusion bodies within renal tubular epithelium.

References

Jan 1, 1991·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D M Haines, B J Chelack
Jan 1, 1970·The British Journal of Dermatology·H BlankC Collins
Jul 31, 1998·Veterinary Pathology·M KiupelD M Haines
Feb 26, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·G M Allan, J A Ellis
Oct 14, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Denise M ImaiN James MacLachlan

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Citations

Feb 3, 2011·Veterinary Research Communications·Zhi-Bang DengXing-Long Yu
Jun 14, 2012·Veterinary Pathology·T Opriessnig, I Langohr
Jan 31, 2017·Archives of Virology·Giuseppe MarruchellaCiriaco Ligios
Jul 7, 2021·Journal of the American Veterinary Medical Association·Courtney N Sweeney, Linden E Craig

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Methods Mentioned

BETA
electron microscopy

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