Porcine circovirus type 2 (PCV2) genotyping in Austrian pigs in the years 2002 to 2017.

BMC Veterinary Research
Christiane Weissenbacher-LangHerbert Weissenböck

Abstract

Eight different PCV2 genotypes with varying prevalence and clinical impact have been described so far. PCV2 infection is still widespread among the vaccinated population and several experimental studies have clearly demonstrated that there is no induction of a 100% cross-protective immunity between the PCV2 genotypes. Hence, PCV2a-based vaccines may be ineffective. In this longitudinal study, the PCV2 genotype and haplotype evolution in Austria in the years 2002 to 2017 was investigated by phylogenetic analysis of 462 bp-long sequences of the capsid protein gene (ORF2). The obtained findings may be of practical relevance for the future development of vaccination strategies. One hundred thirty four of a total of 161 formalin-fixed and paraffin wax-embedded samples could be sequenced successfully. There was no significant influence of storage time on sequencing success or quality. PCV2a (8.2%), PCV2b (77.6%), PCV2d (13.4%), and PCV2g (0.8%) were found. PCV2d was first detected as early as in 2004. PCV2g was described once in 2009. Both global PCV2 genotype shifts were observed. PCV2a occurred with a low prevalence during the first study years only in samples from non-vaccinated swine herds and was gradually replaced by PCV2b unti...Continue Reading

Associated Datasets

References

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Citations

Feb 23, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·T K RajkhowaB Lalrohlua
May 5, 2021·The Veterinary Journal·C UnterwegerA Ladinig

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Methods Mentioned

BETA
PCRs
PCR
electrophoresis

Software Mentioned

Sci Ed Central
SPSS® Statistics
BioNJ
DAMBE
BioEdit Sequence Alignment Editor
BLAST
MEGA X

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