Porcine-derived lung surfactant. A review of the therapeutic efficacy and clinical tolerability of a natural surfactant preparation (Curosurf) in neonatal respiratory distress syndrome

Drugs
L R Wiseman, H M Bryson

Abstract

Porcine-derived lung surfactant (PLS; Curosurf) has shown efficacy in neonatal respiratory distress syndrome. PLS consists of phospholipids, mainly dipalmitoylphosphatidylcholine, the primary surface-active agent of natural lung surfactant, and pulmonary surfactant-associated proteins which facilitate spreading and adsorption of the surface-active agent at the air-alveolar interface. Intratracheal administration of a single dose of PLS 200 mg/kg significantly improves the survival rate and reduces the incidence of bronchopulmonary dysplasia at 28 days in premature infants (birthweight 700 to 2000g) with severe respiratory distress syndrome (fraction of inspired oxygen > or = 0.60). PLS also reduces the incidence of air leak events such as pulmonary interstitial emphysema and pneumothorax. The response rate may be further improved by administration of additional 100 mg/kg doses at 12-hour intervals to infants showing a poor response or relapse after a single dose. PLS prophylaxis reduces the incidence and severity of respiratory distress syndrome in premature infants at high risk of developing the disease; however, it remains unclear whether the eventual clinical outcome is similar or superior to that observed in infants who rec...Continue Reading

Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Sean B Ainsworth, David W A Milligan
Jan 9, 2003·Annual Review of Physiology·James F Lewis, Ruud Veldhuizen
Apr 30, 2005·Biology of the Neonate·A CalkovskaB Robertson
Apr 29, 2000·Acta Anaesthesiologica Scandinavica·H BahlmannB Robertson
Dec 24, 2005·Expert Opinion on Investigational Drugs·Adam Maruscak, Jim F Lewis
Jun 28, 2019·Journal of Korean Medical Science·Chong Woo BaeYong Sung Choi
Sep 6, 2003·Paediatric Drugs·Géraldine Lamboley-GilmertUNKNOWN Neonatologists of the Curosurf Postmarketing French Study
Sep 26, 2001·Clinics in Perinatology·G K Suresh, R F Soll

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