Porcine Endogenous Retrovirus (PERV) - Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells

Frontiers in Microbiology
Krzysztof ŁopataUrszula Mazurek

Abstract

The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infections have been noted in vivo, the possibility of such infections has been confirmed in vitro. Better understanding of the structure and replication cycle of PERVs is a prerequisite for determining the risk of infection and planning PERV-detection strategies. This review presents the current state of knowledge about the structure and replication cycle of PERVs in the context of retroviral infection risk.

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Citations

Jun 13, 2020·Molecular Genetics and Genomics : MGG·S MartheyE Bourneuf
Jan 28, 2020·Xenotransplantation·Adwin ThomasChristopher Burlak
Apr 13, 2021·The Journal of Reproduction and Development·Fuminori TaniharaTakeshige Otoi

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Methods Mentioned

BETA
medical procedure
xenograft
gene knock-out
genetic modifications
glycosylation
histone acetylation
xenografts
scanning electron microscopy
genetic modification

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