PMID: 9192164Jun 1, 1997Paper

Porcine model of proliferative vitreoretinopathy with platelets

Current Eye Research
A García-LayanaG Gonzalez

Abstract

To develop an experimental model of proliferative vitreoretinopathy (PVR) in the pig, and determine the efficacy of platelet-derived growth factor (PDGF) compared with different platelet plasma concentrates in its development. Animals were divided into four groups of 12 pigs each. Group 1, 2, and 3 underwent four 3-mm-long retinotomies, a partial mechanical vitrectomy, and six transconjunctival retinal cryoapplications and were injected intravitreally with, respectively, 0.2 ml of platelet rich plasma, 0.2 ml of a solution containing 200 ng of porcine PDGF, and 0.2 ml of platelet concentrated plasma. Group 4 received only an intravitreal injection of 0.2 ml of porcine PDGF. In Group 1, retinal detachments (RDs) developed in six eyes (50%) (two eyes, total RDs; four, extensive RDs). In Group 2, focal RDs developed in six eyes (50%). In Group 3, 11 eyes (92%) developed Rds (six eyes, total RDs; three, extensive RDs, two, focal RDs). Group 4, did not develop lesions. Statistically significant differences were found between Group 3 and the other groups. Group 2 RDs were associated with the presence of vitreoretinal membranes but there were no signs of PVR. In Groups 1 and 3, signs of anterior PVR, posterior PVR, and retinal holes w...Continue Reading

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Citations

Apr 3, 2007·Nature Protocols·Rajat N AgrawalDavid R Hinton
Dec 3, 2013·Xenotransplantation·Elizaveta Fasler-KanPeter Meyer
Jan 21, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ulrica Englund JohanssonKarin Warfvinge
Aug 4, 2020·Translational Vision Science & Technology·Rishika ChaudharyRichard J Blanch

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