PMID: 9533281Apr 9, 1998Paper

Porcine nephropathy in Bulgaria: a progressive syndrome of complex or uncertain (mycotoxin) aetiology

The Veterinary Record
Stoycho D StoevPeter Mantle

Abstract

Macroscopic nephropathy was observed in 506 pigs at slaughter in Bulgaria in 1993/94. Histopathological changes were mainly degenerative and proliferative, and were linked with kidney hypertrophy similar to that of the classical Danish Syndrome. Retention cysts formed by dilated tubules, activation or proliferation of capillary and vascular endothelium, and the development of neoplastic tissue were also observed. The most advanced pathology took the form of extensive interstitial fibrosis. Traces of ochratoxin A were found in the kidneys of the majority of 96 cases examined, and in some feed samples taken retrospectively from farms or commercial sources. The dietary ochratoxin concentration (100 micrograms/kg), calculated from serum analyses, closely matched the average of individually analysed feeds. In other feeds no ochratoxin A was detected and the cosmopolitan mycobiota isolated did not include the ochratoxinogenic Penicillium verrucosum that caused the Danish syndrome. Aspergillus ochraceus was rare and the isolates did not synthesise ochratoxin in laboratory culture. The unconfirmed diagnosis of ochratoxicosis suggests a complex or multi-toxin aetiology for this rather common chronic disease in Bulgaria.

References

Jul 1, 1984·Australian Veterinary Journal·M O Tapia, A A Seawright
Mar 1, 1980·Applied and Environmental Microbiology·A D Hocking, J I Pitt
May 15, 1998·The Veterinary Record·F J PeñaB Alegre

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Citations

Feb 1, 2010·Mycotoxin Research·Stoycho D StoevIordan Petkov
Feb 1, 2010·Mycotoxin Research·Patrick B NjobehJoseph S Mosonik
Jul 10, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G MüllerH Köhler
Sep 16, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·S D StoevP A Steenkamp
Jun 19, 2013·Critical Reviews in Food Science and Nutrition·Stoycho D Stoev
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Annie Pfohl-Leszkowicz
Mar 28, 2009·International Journal of Molecular Sciences·Stoycho D Stoev
Nov 6, 2013·Toxins·Maja Segvić KlarićMaja Peraica
Mar 4, 2005·Critical Reviews in Toxicology·Evelyn O'Brien, Daniel R Dietrich
Feb 24, 2009·Chemosphere·Yasser Said El-SayedTalaat Talaat Saad
Dec 13, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Alexandra H HeussnerEvelyn O'Brien
Sep 6, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A H HeussnerE O'Brien
Apr 3, 2002·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·S D StoevP G Mantle
Jun 10, 2000·Journal of Veterinary Pharmacology and Therapeutics·E Petzinger, K Ziegler
Dec 24, 2005·Journal of Bioinformatics and Computational Biology·Manuel GilGaston H Gonnet
Apr 11, 2014·Current Opinion in Nephrology and Hypertension·Annika WernersonCarl-Gustaf Elinder
Nov 20, 2012·Toxins·Patrick B NjobehPer Haggblom
Jun 23, 2020·Toxicon : Official Journal of the International Society on Toxinology·Stoycho D Stoev

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