Porcine Prediction of Pharmacokinetic Parameters in People: A Pig in a Poke?

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Huadong Tang, Michael Mayersohn

Abstract

The minipig has become an animal of considerable interest in preclinical drug development. It has been used in toxicology research and in examining/establishing regulatory guidelines as a nonrodent animal model. We have reviewed some basic issues that one would want to consider in the development and testing of any animal model for humans. The pig is a reasonable alternative to the dog, but there are some clear limitations and unexplained disparities in the literature, which require further study; primary among these is the need for standardization in choice of breed and sex and routine protocols. The minipig offers numerous advantages over other established animal models, and it has similarities to the human with regard to anatomy, physiology, and biochemistry. The gastrointestinal tract is structurally and functionally similar to humans. This appears to be true for enzymes and transporters in the gut as well, but more study is needed. One major concern is assessment of oral drug absorption, especially with regard to potential food effects due to gastric emptying differences, yet this does not appear to be a consistent observation. Hepatic metabolism seems to reflect enzymatic patterns in humans, with some differences. Kidney ...Continue Reading

References

Jan 1, 1979·European Journal of Clinical Pharmacology·J V WillisP G Welling
Nov 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P Nielsen, L Dalgaard
Jul 1, 1990·The Journal of Pharmacy and Pharmacology·J Príborský, E Mühlbachová
Mar 1, 1991·Journal of Applied Physiology·M D McKirnanF C White
Jan 1, 1991·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·F AuclairJ Wepierre
Nov 1, 1990·Pharmaceutical Research·M HossainJ W Ayres
Mar 27, 1968·Annals of the New York Academy of Sciences·R E DoyleF W Clayton
Aug 1, 1968·Journal of Pharmaceutical Sciences·K B Bischoff, R L Dedrick
Oct 1, 1994·Veterinary Immunology and Immunopathology·D H Sachs
May 1, 1994·Pharmaceutical Research·R L OberleR J Sawchuk
May 1, 1996·Clinical Pharmacology and Therapeutics·K E ThummelG R Wilkinson
Sep 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I Mahmood, J D Balian
Jan 1, 1997·Pharmaceutical Research·S RohatagiA R DiSanto
Jan 1, 1997·Pharmacology & Toxicology·M T Skaanild, C Friis
Jan 14, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P ClarysV Préat
Feb 5, 1999·Surgical and Radiologic Anatomy : SRA·J P RicherM Carretier
Mar 22, 2000·Journal of Agricultural and Food Chemistry·G J Diaz, E J Squires
Feb 24, 2001·The Journal of Pharmacy and Pharmacology·S S DavisM Hinchcliffe
Apr 20, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J J BogaardsB Walther
Nov 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Omar Ghosheh, Edward M Hawes
Apr 24, 1964·Annals of the New York Academy of Sciences·F L EARLO G FITZHUGH
Nov 19, 2003·Pharmaceutical Research·Stéphane Mouly, Mary F Paine
Mar 3, 2004·Journal of Biochemical and Molecular Toxicology·Huadong TangMichael Mayersohn
May 28, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huadong Tang, Michael Mayersohn
May 28, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huadong Tang, Michael Mayersohn
Jun 17, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huadong Tang, Michael Mayersohn
Apr 14, 2006·Current Pharmaceutical Design·Mette Tingleff Skaanild
Apr 20, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Niclas PetriHans Lennernäs
Jun 17, 2006·Pharmaceutical Research·Jeffery J PrusakiewiczRichard Voorman
Nov 1, 2006·Journal of Pharmaceutical Sciences·Kimberley A LentzPunit H Marathe
Feb 3, 2007·Nature Reviews. Drug Discovery·Amin Rostami-Hodjegan, Geoffrey T Tucker
Jul 25, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huadong TangEric Fluhler
Jun 10, 1966·Science·L K Bustad, R O McClellan
Dec 7, 2007·Drug Metabolism Reviews·Franz OeschRobert Landsiedel
Sep 9, 2008·Journal of Pharmacological and Toxicological Methods·Richard N Upton
Aug 27, 2009·Skin Pharmacology and Physiology·T J FranzS G Raney
Jul 6, 2010·Journal of Pharmacological and Toxicological Methods·Jan Willem van der LaanUNKNOWN Steering Group of the RETHINK Project
Dec 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M MonshouwerA S van Miert

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Citations

Oct 20, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Aarti Sawant-Basak, R Scott Obach
Oct 31, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Soo K ShinFranklin D West
Dec 9, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lene Lundgaard DonovanGitte Moos Knudsen
Jan 6, 2021·Pharmaceutics·Miriam AyusoSteven Van Cruchten
Feb 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wim SchelstraeteSiska Croubels
Apr 16, 2021·Laboratory Animals·Kristoffer KjærgaardAage Kristian Olsen Alstrup
Apr 27, 2021·American Journal of Physiology. Renal Physiology·Jianni HuangShougang Zhuang
Nov 25, 2021·Science Translational Medicine·Joan K LunneyChaohui Dai

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