Porcine rotavirus bearing an aberrant gene stemming from an intergenic recombination of the NSP2 and NSP5 genes is defective and interfering.

Journal of Virology
Dianjun CaoYasutaka Hoshino

Abstract

Serial undiluted passage of a porcine rotavirus in MA104 cells yielded three distinct virus populations, each of which bore different rearranged genes. Sequencing revealed that each of two populations bore a distinct intragenic recombinant NSP3 gene consisting of a partial duplication in a head-to-tail orientation without altering the NSP3 open reading frame and the third population carried both an intragenic recombinant NSP3 gene and an intergenic recombinant gene (1,647 nucleotides in length) which contained a truncated NSP2 gene inserted into the NSP5 gene at residue 332. The former two populations were viable, whereas the latter population was defective and interfering.

References

Mar 1, 1992·Journal of Virology·P R LambdenI N Clarke
Jan 1, 1987·Archives of Virology·B BiryahwahoU Desselberger
Dec 1, 1985·The Journal of General Virology·A M Allen, U Desselberger
Aug 1, 1970·Journal of Virology·M NonoyamaA F Graham
Apr 24, 1981·Nucleic Acids Research·B A Moss, G G Brownlee
Oct 1, 1993·Trends in Microbiology·C R Bangham, T B Kirkwood
Jan 1, 1997·Annual Review of Microbiology·R F Ramig
Aug 20, 2002·The Journal of General Virology·A C PotgieterA A van Dijk
Feb 24, 2006·Emerging Infectious Diseases·Umesh D ParasharRoger I Glass
Jul 25, 2006·Lancet·Roger I GlassJon R Gentsch
Aug 17, 2006·Current Topics in Microbiology and Immunology·J T PattonZ F Taraporewala

❮ Previous
Next ❯

Citations

Jun 5, 2010·Molecular Biology and Evolution·Jelle MatthijnssensMarc Van Ranst
Mar 15, 2013·Molecular Biology and Evolution·Etienne Simon-Loriere, Edward C Holmes
Aug 13, 2010·Journal of Virology·Cheng-Qiang HeHong-Shan Guo
Oct 1, 2011·Future Microbiology·Souvik Ghosh, Nobumichi Kobayashi
Oct 12, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mokibul Hassan AfradMustafizur Rahman
Oct 25, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Khuzwayo C JereHester G O'Neill
Jun 22, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nicole C DonkerCarl D Kirkwood
Jul 13, 2014·Virus Research·Ulrich Desselberger
Mar 16, 2018·Microbiology and Molecular Biology Reviews : MMBR·Vadim I Agol, Anatoly P Gmyl
Jan 18, 2020·Virus Evolution·Irene Hoxie, John J Dennehy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.