Pore formation mechanism of porous poly(DL-lactic acid) matrix membrane

Materials Science & Engineering. C, Materials for Biological Applications
Thawatchai Phaechamud, Sasiprapa Chitrattha

Abstract

Porous PLA structure has been widely used in cell transplantation, drug carrier and wound dressing. The porous structure can be controlled depending on the choice of the polymer, solvent, nonsolvent and preparation parameters. In this study, the porous PLA matrix membranes were prepared by adding PEG 400 in PLA solution using dichloromethane (DCM) as solvent prior to casting. The influence of other liquids as co-solvent on pore formation and the structural change during membrane formation were evaluated. The co-solvents affected both porous topography and mechanical properties of PLA membrane. The porous matrix were produced when the non-solvent of PLA was used as co-solvent. Cryo-SEM micrographs revealed that PEG 400 still remained in the PLA porous matrix membrane. From the tracking of the structural change during film formation, the PLA-PEG solution changed into porous structure by liquid liquid phase separation and solidification processes, respectively. Thermogravimetric analysis revealed that PLA-PEG in DCM solution exhibited the two-step of weight loss, the first step occurred from DCM evaporation and the second step occurred from the degradation of PLA-PEG matrix. The liquid-liquid phase separation and solidification st...Continue Reading

References

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Nov 3, 2012·Advanced Materials·Yosuke OkamuraShinji Takeoka
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Sasiprapa Chitrattha, Thawatchai Phaechamud

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