Pore size-dependent immunogenic activity of mesoporous silica-based adjuvants in cancer immunotherapy

Journal of Biomedical Materials Research. Part a
Xiupeng WangTadao Ohno

Abstract

Commonly used aluminum hydroxide (Alum) adjuvant provokes a strong type 2 helper T cell (Th2) response for mediating antibody production but is rather ineffective for disease prevention that requires type 1 helper T cell (Th1) response for mediating cellular immunity in human vaccination. Here, for the purpose of inducing Th1 antitumor immunity, a mesoporous silica (MS)-based adjuvant is prepared. Three kinds of MS particles with nearly identical particle size and surface area but different pore sizes of 4, 7 and 10 nm were prepared. No serious in vitro cytotoxicity was observed for the MS particles at 5, 20, 50, and 100 μg/mL. Pathogen-associated molecular patterns (PAMPs) were immobilized with apatite (Ap) on MS to prepare the MS-based and PAMP-loaded adjuvants (MS-Ap-PAMP adjuvants). Macrophage-like cells cultured in the presence of MS-Ap-PAMP adjuvant with a MS pore size of 10 nm showed the maximum in vitro immunogenic activity. Injection of the MS-Ap-PAMP adjuvant with a MS pore size of 10 nm in combination with liquid nitrogen-treated tumor tissue (derived from Lewis lung carcinoma cells) to C57BL/6 mice markedly inhibited the development of rechallenged tumor in vivo, while no such antitumor immunity was induced in injec...Continue Reading

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Citations

Dec 25, 2015·Colloids and Surfaces. B, Biointerfaces·Xiupeng WangNoriko M Tsuji
Dec 17, 2014·The Journal of Pharmacy and Pharmacology·Charlotte N MaughanGareth R Williams
Feb 18, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Michał Moritz, Małgorzata Geszke-Moritz
Jun 19, 2018·Chemical Society Reviews·Xia LiAtsuo Ito
Mar 19, 2016·Advanced Healthcare Materials·Xiupeng WangAtsuo Ito
Jan 13, 2018·Chemical Communications : Chem Comm·Xiupeng WangNoriko M Tsuji
Nov 24, 2018·Colloids and Surfaces. B, Biointerfaces·Xiupeng WangAtsushi Yamazaki
Feb 11, 2021·Recent Patents on Anti-cancer Drug Discovery·Yu YanXiaoyu Li

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