Porous chitosan microspheres for application as quick in vitro and in vivo hemostat

Materials Science & Engineering. C, Materials for Biological Applications
Jixiang LiHaiqing Liu

Abstract

Controlling massive hemorrhage is of great importance to lower transfusional medical cost, and to reduce death and mobility rate in battlefield and civilian accidents. We reported the fabrication of porous chitosan microspheres (CSMS) with tunable surface pore size by microemulsion combined with thermally induced phase separation technique, and its application as a quick hemostat. Their hemostatic property was characterized by blood clotting kinetics, adherence interaction between red blood cells/platelets and CSMS, in vitro and in vivo hemostasis by rat tail amputation and liver laceration models, and histological analysis. Their density, surface area, porosity, water absorption ratio were 0.04-0.06g/cm(3), 28.2-31.5m(2)/g, 98%, and 15.5-23.2g/g, respectively. The surface pore was controlled to be smaller than 2.0μm. The porous CSMS showed increasing hemostatic efficacy with decreasing surface pore size. Compared to the conventional compact chitosan particles (CCSP), the porous CSMS had much improved in vitro and in vivo hemostatic potential with respect to formation of blood clot, hemostatic time, and blood loss. For instance, the hemostatic time and blood loss of CSMS in the rat liver laceration model were down to respective...Continue Reading

Citations

Feb 16, 2020·Journal of Biomedical Materials Research. Part a·Lindy K JangDuncan J Maitland
Apr 30, 2020·Journal of Biomaterials Science. Polymer Edition·Yong ZhaoXulin Jiang
Aug 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ruihua CuiChangsheng Liu
Nov 26, 2020·Biomimetics·Sara Isabel Zamora LagosCarlos David Grande Tovar
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Yi-Fan ShenJing-Feng Li
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Xiaohong LiGuang Yang
Apr 30, 2021·Carbohydrate Polymers·Xiaohui WeiFeng Tian
Aug 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huitong ChengChangsheng Zhao
Sep 28, 2021·ACS Applied Bio Materials·Anand Utpal VakilMary Beth B Monroe

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