Porous gelatin particles for uterine artery embolization: an experimental study of intra-arterial distribution, uterine necrosis, and inflammation in a porcine model

Cardiovascular and Interventional Radiology
Miyuki SoneKatsuyuki Aozasa

Abstract

We evaluated the location of porous gelatin particles (GP; Gelpart; Nippon Kayaku/Astellas, Tokyo, Japan) within the arterial vasculature and their acute effects on uterine necrosis and inflammation after uterine artery embolization (UAE) in swine. Adult nonpregnant pigs (n = 6) were allocated to either 1- (n = 3) or 2-mm GP (n = 3). Superselective and bilateral embolization of the uterine arteries was performed. All animals were killed 1 week after UAE. Macroscopic and microscopic findings, including the level of arterial occlusion and their effect on uterine necrosis and inflammation, were analyzed. All UAE procedures were completed without severe complications. The macroscopic necrosis was seen in two animals in the 2-mm group with an extent of <50%. The location of the occluded arteries did not differ significantly between groups. The median diameters of the occluded arteries were 449 microm (95% confidence interval [CI] 417-538 microm) in the 1-mm GP group and 484 microm (95% CI 370-560 microm) in the 2-mm GP group. As for microscopic necrosis, no statistically significant difference was observed. The qualitative inflammatory reaction was significantly greater in the 2-mm GP group than in the 1-mm group (p < 0.001). Both 1...Continue Reading

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Citations

Jun 29, 2011·Cardiovascular and Interventional Radiology·Wen-Quan ZhuangJian-Yong Yang
Jul 19, 2012·International Journal of Clinical Oncology·Keigo OsugaNoriyuki Tomiyama
Feb 11, 2014·Japanese Journal of Radiology·Shiro MiyayamaYasuo Nakajima
Apr 3, 2012·Journal of Vascular and Interventional Radiology : JVIR·Ulrike Stampfl, Goetz M Richter
Feb 19, 2014·Journal of Vascular and Interventional Radiology : JVIR·Tetsuya MasadaKimihiko Kichikawa
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Sep 3, 2013·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Yun Gyu SongChang-Woon Kim

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