Porous implants as drug delivery vehicles to augment host tissue integration

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Paul A ClarkJeremy J Mao

Abstract

The common premise of synthetic implants in the restoration of diseased tissues and organs is to use inert and solid materials. Here, a porous titanium implant was fabricated for the delivery of microencapsulated bioactive cues. Control-released transforming growth factor-beta1 (TGF-beta1) promoted the proliferation and migration of human mesenchymal stem cells into porous implants in vitro. At 4 wk of implantation in the rabbit humerus, control-released TGF-beta1 from porous implants significantly increased bone-to-implant contact (BIC) by 96% and bone ingrowth by 50% over placebos. Control-released 100 ng TGF-beta1 induced equivalent BIC and bone ingrowth to adsorbed 1 microg TGF-beta1, suggesting that controlled release is effective at 10-fold less drug dose than adsorption. Histomorphometry, scanning electron microscopy, and microcomputed tomography showed that control-released TGF-beta1 enhanced bone ingrowth in the implant's pores and surface. These findings suggest that solid prostheses can be transformed into porous implants to serve as drug delivery carriers, from which control-released bioactive cues augment host tissue integration.

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Citations

Dec 28, 2011·Journal of Materials Science. Materials in Medicine·Cheng XieYi-Min Zhao
Mar 30, 2012·Biomedical Materials·Esha S DesaiRichard A Gemeinhart
Nov 7, 2009·Tissue Engineering. Part B, Reviews·Jeremy J MaoJeffrey Ahn
Jul 24, 2012·Therapeutic Delivery·Kyung Jae Jeong, Daniel S Kohane
May 31, 2015·Advanced Drug Delivery Reviews·Siew-Min OngSiew-Cheng Wong
Feb 22, 2011·International Journal of Pharmaceutics·Luis Manuel PerezJesús Santamaría
Jun 1, 2010·Seminars in Orthodontics·Jeremy J Mao
Sep 10, 2010·Journal of Tissue Engineering and Regenerative Medicine·Beili ZhuC Mauli Agrawal
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Silvia LopaMatteo Moretti
Oct 29, 2014·Tissue Engineering. Part B, Reviews·Eric Alexander LewallenAndre J van Wijnen
Dec 3, 2014·Biomaterials·Hyun-Do JungJuha Song
May 21, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Nicholas M BernthalFrank A Petrigliano
Jan 15, 2019·Techniques in Orthopaedics : TIO·Zachary D C BurkeNicholas M Bernthal

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