Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications

Current Medicinal Chemistry
Junling GuoJoseph J Richardson

Abstract

Porous micro- and nanoparticles have the capacity to encapsulate a large quantity of therapeutics, making them promising delivery vehicles for a variety of applications. This review aims to highlight the latest development of inorganic and hybrid (inorganic/ organic) particles for drug delivery with an additional emphasis on combatting drug resistant cancer. We go one step further and discuss delivery applications beyond medicinal delivery, as there is generally a translation from medicinal delivery to botanic delivery after a short lag time. We undertook a search of relevant peer-reviewed publications. The quality of the relevant papers was appraised using standard tools. The characteristics of the papers are described herein, and the relevant material and therapeutic properties are discussed. We discuss 4 classes of porous particles in terms of drug delivery and theranostics. We specifically focus on silica, calcium carbonate, metal-phenolic network, and metalorganic framework particles. Other relevant biomedically relevant applications are discussed and we highlight outstanding therapeutic results in the relevant literature. The findings of this review confirm the importance of studying and utilizing porous particles for the...Continue Reading

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Citations

Jan 26, 2020·Nanomaterials·Ylenia JabaleraJaime Gómez-Morales
Sep 14, 2019·Current Medicinal Chemistry·Giovanni Luca Beretta
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Amin AmaniMahdi Nohtani
Jul 3, 2020·International Journal of Biological Macromolecules·Avinash Singh PatelPraveen Kumar Sappati

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