Porous, lithium-doped calcium polyphosphate composite scaffolds containing vascular endothelial growth factor (VEGF)-loaded gelatin microspheres for treating glucocorticoid-induced osteonecrosis of the femoral head

Biomedical Materials
Yue LuoPengde Kang

Abstract

Glucocorticoids-induced osteonecrosis of femoral head (GIONFH) is difficult to treat due to the pathophysiology remains uncertain. Core decompression and bone grafting are regarded as effective measures for treating early GIONFH. Furthermore, commonly used bone graft materials at nowadays are still unsatisfactory. We generated a novel calcium polyphosphate (CPP) composite scaffold, which contains Li and VEGF-loaded gelatin microspheres (LiCPP/GMs/VEGF). The LiCPP/GMs/VEGF scaffold also demonstrated a porosity of 70.5% ± 2.3% with interconnected porous structures, and pore sizes of 100-200 μm and compressive strength of 3.7 MPa. Additionally, bone marrow mesenchymal stem cells (BMSCs) were seeded on scaffolds in vitro. Further characterization showed that the LiCPP/GMs/VEGF scaffolds were biocompatible and enhanced osteogenesis and angiogenesis in vitro. Using a rabbit model of GIONFH, LiCPP/GMs/VEGF scaffolds were implanted into the bone tunnels of core decompression in the femoral head for 12 weeks. Radiographic, histological analysis and western blot analysis demonstrated that the LiCPP/GMs/VEGF scaffolds exhibited good biocompatibility, and osteogenic and angiogenic activity in vivo. Besides, the osteogenic and angiogenic fa...Continue Reading

References

Jan 1, 1969·Scandinavian Journal of Plastic and Reconstructive Surgery·P I BrånemarkA Ohlsson
Sep 1, 1993·The Journal of Bone and Joint Surgery. American Volume·T D BrownR A Brand
May 1, 1997·Developmental Biology·C M HedgepethP S Klein
Jun 1, 1997·Clinical Orthopaedics and Related Research·J A GouletM L Greenfield
Jan 26, 1999·Clinical Orthopaedics and Related Research·J Glowacki
Jan 22, 2003·Biochemical and Biophysical Research Communications·Gerard BainJackie Papkoff
Apr 28, 2004·Biochemical and Biophysical Research Communications·Keizo OhnakaRyoichi Takayanagi
Jun 19, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Xudong LiGary Balian
May 27, 2005·Advances in Biochemical Engineering/biotechnology·Amit S Mistry, Antonios G Mikos
Apr 25, 2006·Nature Reviews. Molecular Cell Biology·Anna-Karin OlssonLena Claesson-Welsh
Jan 30, 2007·The Journal of Bone and Joint Surgery. British Volume·T T TangJ R Lou
Oct 17, 2007·Journal of Orthopaedic Surgery and Research·Hui H ShengLing L Qin
Feb 20, 2008·Acta Orthopaedica·Anders PalmquistPeter Thomsen
Nov 11, 2008·Bone·Ali ZamaniMasoud Mousavi Nasab
Feb 24, 2009·Biomaterials·Diederik H R KempenWouter J A Dhert
Oct 3, 2009·The Journal of Bone and Joint Surgery. American Volume·Chun-Chieh ChenMel S Lee
Sep 17, 2010·The Journal of Bone and Joint Surgery. American Volume·Michael A MontRonald E Delanois
Dec 17, 2010·Clinical Reviews in Allergy & Immunology·Christian PowellM Eric Gershwin
Mar 2, 2011·Investigative Ophthalmology & Visual Science·Martin N NakatsuSophie X Deng
Apr 6, 2011·The Journal of Bone and Joint Surgery. British Volume·X H XieL Qin
May 24, 2011·Chemical Society Reviews·Qian YeWeimin Liu
Feb 9, 2012·Journal of Materials Science. Materials in Medicine·Huixu XieLongjiang Li
Feb 23, 2013·Journal of Materials Science. Materials in Medicine·Zhipeng GuXixun Yu
Jun 9, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Wei LiAldo R Boccaccini
Jul 6, 2015·Current Reviews in Musculoskeletal Medicine·Kalpit N ShahRoy K Aaron
Sep 24, 2015·World Journal of Orthopedics·Joaquin Moya-AngelerJoseph M Lane

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