Porous magnesium aluminometasilicate tablets as carrier of a cyclosporine self-emulsifying formulation.

AAPS PharmSciTech
Camilla Sander, Per Holm

Abstract

The aim of this study was to investigate the ability of liquid loadable tablets (LLT) to be loaded with a self-microemulsifying drug delivery system (SMEDDS) containing cyclosporine (CyA). LLT were prepared by direct compression of the porous carrier magnesium aluminometasilicate and subsequently loaded with SMEDDS by a simple absorption method. SMEDDS was evaluated regarding visual appearance and droplet size distribution after dispersion in aqueous media. The developed SMEDDS was found to be similar to Neoral. LLT were characterized before and after loading regarding weight variation, tablet hardness, disintegration time, and in vitro drug release. It was found that LLT with high porosities suitable for liquid loading and further processing could be prepared. Adding a tablet disintegrant was found to improve in vitro drug release. Additionally, the volume-based loading capacity of LLT was evaluated and found to be comparable to soft gelatin and hard two-piece capsules. Furthermore, the pharmacokinetic performance of CyA from loaded LLT was tested in two PK-studies in dogs. Absorption of CyA from SMEDDS loaded into LLT was found in the first study to be significantly lower than the absorption of CyA from SMEDDS filled into a c...Continue Reading

References

Dec 9, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Johanna Mercke OdebergPeter Höglund
Apr 6, 2006·AAPS PharmSciTech·Pradeep Patil, Anant Paradkar
Jul 4, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Colin W Pouton
Aug 29, 2006·Drug Discovery Today·Jagdish L ItaliaM N V Ravi Kumar
Mar 3, 2007·Nature Reviews. Drug Discovery·Christopher J H PorterWilliam N Charman
Sep 7, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R H MüllerE B Souto
Nov 30, 2007·Advanced Drug Delivery Reviews·V JanninD Marchaud
Jun 11, 2008·Critical Reviews in Therapeutic Drug Carrier Systems·Tripta BansalSushama Talegaonkar
Jul 8, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tao YiXiangliang Yang
Jul 26, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·R P Dixit, M S Nagarsenker
Mar 1, 2006·AAPS PharmSciTech·Pradeep Patil, Anant Paradkar

❮ Previous
Next ❯

Citations

Apr 13, 2013·International Journal of Pharmaceutics·Huiling MuAnette Müllertz
Dec 10, 2013·Colloids and Surfaces. B, Biointerfaces·Swati PundSujata Jagadale
Feb 27, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Daniel PreisigMaxim Puchkov
Nov 2, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Swati PundGanesh Rasve
Apr 12, 2011·Drug Development and Industrial Pharmacy·Myung Joo KangSang-Cheol Chi
Apr 1, 2011·Drug Development and Industrial Pharmacy·Christina M HentzschelClaudia S Leopold
Oct 4, 2011·Drug Development and Industrial Pharmacy·C M HentzschelC S Leopold
Mar 29, 2014·Drug Delivery·Shambhu Dokania, Amita K Joshi
Mar 8, 2013·Drug Development and Industrial Pharmacy·Ashish Deshmukh, Shirishkumar Kulkarni
Oct 20, 2015·Expert Opinion on Drug Delivery·Gintare Leonaviciute, Andreas Bernkop-Schnürch
Jan 1, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Claudia KutzaKarsten Mäder
Jun 7, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara BiagiottiMauro Magnani
Dec 18, 2013·Journal of Veterinary Internal Medicine·T M ArcherA J Mackin
Apr 20, 2016·Advanced Drug Delivery Reviews·Orlagh M FeeneyChristopher J H Porter
Nov 19, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Martin Lau ChristiansenAnette Müllertz
Sep 24, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Philip Carsten ChristophersenAnette Müllertz
Feb 13, 2013·Carbohydrate Polymers·Yuanrui HuangLiangke Zhang
Mar 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Inga MatulyteJurga Bernatoniene
Aug 14, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Indrani MajiPankaj Kumar Singh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.